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This effect was abolished in mice with impaired GR function. In summary, we uncovered a novel GR\u2010miR\u201029a negative feedback loop conserved between mice and humans, in health and disease. For the first time, we elucidate a microRNA\u2010related mechanism that might contribute to GR dysregulation and resistance in peripheral tissues.\u2014Glantschnig, C, Koenen, M., Gil\u2010Lozano, M., Karbiener, M., Pickrahn, I., Williams\u2010Dautovich, J., Patel, R., Cummins, C. L., Giroud, M., Hartleben, G., Vogl, E., Bl\u00fcher, M., Tuckermann, J., Uhlenhaut, H., Herzig, S., Scheideier, M. A. miR\u201029a\u2013driven negative feedback loop regulates peripheral glucocorticoid receptor signaling. 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