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Fas has already been established as the regulator of inflammation in RA, but its role in bone formation under arthritic conditions is not completely defined. The aim of this study was to assess the effect of Fas inactivation on the bone damage during murine antigen\u2010induced arthritis. Subchondral bone of wild\u2010type (WT) and Fas\u2010knockout (Fas\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice was evaluated by histomorphometry and microcomputerized tomography. Proportions of synovial bone and cartilage progenitors were assessed by flow cytometry. Synovial bone and cartilage progenitors were purified by fluorescence\u2010activated cell sorting and expression of Fas and Fas\u2010induced apoptosis were analyzed\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Results showed that Fas\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice developed attenuated arthritis characterized by preserved epiphyseal bone and cartilage. A proportion of the earliest CD200\n                    <jats:sup>+<\/jats:sup>\n                    bone and cartilage progenitors was reduced in WT mice with arthritis and was unaltered in Fas\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. During osteoblastic differentiation\n                    <jats:italic>in vitro<\/jats:italic>\n                    , CD200\n                    <jats:sup>+<\/jats:sup>\n                    cells express the highest levels of Fas and are removed by Fas ligation. These results suggest that Fas\u2010induced apoptosis of early CD200\n                    <jats:sup>+<\/jats:sup>\n                    osteoprogenitor population represents potential mechanism underlying the impaired bone formation in arthritis, so their preservation may represent the bone\u2010protective mechanism during arthritis.\u2014Lazi\u0107 Mosler, E., Luka\u010d, N., Flegar, D., Fadljevi\u0107, M., Radanovi\u0107, I., Cvija, H., Kelava, T., Iv\u010devi\u0107, S., \u0160u\u0107ur, A., Markoti\u0107, A., Katavi\u0107, V., Maru\u0161i\u0107, A., Gr\u010devi\u0107, D., Kova\u010di\u0107, N. Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen\u2010induced arthritis. FASEB J. 33, 3330\u20133342 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801426r","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T16:39:38Z","timestamp":1541090378000},"page":"3330-3342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen\u2010induced arthritis"],"prefix":"10.1096","volume":"33","author":[{"given":"Elvira Lazi\u0107","family":"Mosler","sequence":"first","affiliation":[{"name":"Laboratory for Molecular Immunology Croatian Institute for Brain Research University of Zagreb School of Medicine  Zagreb Croatia"},{"name":"Department of Dermatology and Venerology General Hospital Dr. Ivo Pedi\u0161i\u0107  Sisak Croatia"},{"name":"Department of Nursing Catholic University of Croatia  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Luka\u010d","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Immunology Croatian Institute for Brain Research University of Zagreb School of Medicine  Zagreb Croatia"},{"name":"Department of Anatomy University of Zagreb School of Medicine  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darja","family":"Flegar","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Immunology Croatian Institute for Brain Research University of Zagreb School of Medicine  Zagreb Croatia"},{"name":"Department of Physiology and Immunology University of Zagreb School of Medicine  Zagreb 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