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The\n                    <jats:italic>in vitro<\/jats:italic>\n                    potency of xGLP159 and xGLP296 were investigated on human embryonic kidney 293 cells. The acute glucose\u2010lowering and insulinotropic effects of xGLP159 and xGLP296 were assessed in the Institute of Cancer Research, Kunming, and diabetic (\n                    <jats:italic>db\/db<\/jats:italic>\n                    ) mice. The pharmacokinetic profiles of xGLP159 and xGLP296 were confirmed on Sprague\u2010Dawley (SD) rats and their long\u2010acting hypoglycemic and anorectic effects were evaluated in\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice. Chronic treatment effects of xGLP159 and xGLP296 were evaluated in diet\u2010induced obese (DIO) mice and\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice. The results showed that xGLP159 and xGLP296 exhibited comparable receptor activation potency, hypoglycemic effect, and insulinotropic activity to liraglutide. The enhanced half\u2010lives of xGLP159 and xGLP296 in SD rats (5.1 and 5.8 h, respectively) resulted in prolonged anti\u2010\n                    <jats:italic>db<\/jats:italic>\n                    \/\n                    <jats:italic>db<\/jats:italic>\n                    durations in\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice. Three weeks' administration of xGLP159 and xGLP296 normalized glucose tolerance and adiposity in DIO mice. Furthermore, 11\u2010wk treatment of xGLP159 and xGLP296 corrected hyperglycemia and improved pancreatic function in\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice. These preclinical studies supported xGLP159 and xGLP296 as promising candidates for the treatment of metabolic diseases.\u2014Han, J., Meng, T., Chen, X., Han, Y., Fu, J., Zhou, F., Fei, Y., Li, C. The chronic administration of two novel long\u2010acting\n                    <jats:italic>Xenopus<\/jats:italic>\n                    glucagon\u2010like peptide\u20101 analogs xGLP159 and xGLP296 potently improved systemic metabolism and glycemie control in rodent models. FASEB J. 33, 7113\u20137125 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801479r","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T13:42:04Z","timestamp":1552398124000},"page":"7113-7125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The chronic administration of two novel long\u2010acting\n                    <i>Xenopus<\/i>\n                    glucagon\u2010like peptide\u20101 analogs xGLP159 and XGLP296 potently improved systemic metabolism and glycemic control in rodent models"],"prefix":"10.1096","volume":"33","author":[{"given":"Jing","family":"Han","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University Xuzhou China"},{"name":"School of Chemistry and Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Fei","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.05.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.01.029"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.209"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6b00787"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:29:1:61"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp5002685"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700002R"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500810s"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00787"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.140"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61335-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00726"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.01.024"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm070861j"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/bph.14107","article-title":"Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities","volume":"175","author":"Han J.","year":"2018","journal-title":"Br. 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