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Epidemiologic and experimental studies have revealed a correlation between hyperhomocysteinemia and hearing loss. Here, we have studied the expression of methionine cycle genes in the mouse cochlea and the impact of knocking out the\n                    <jats:italic>Bhmt<\/jats:italic>\n                    gene in the auditory receptor. We evaluated age\u2010related changes in mouse hearing by recording auditory brainstem responses before and following exposure to noise. Also, we measured cochlear cytoarchitecture, gene expression by RNA\u2010arrays and quantitative RT\u2010PCR, and metabolite levels in liver and plasma by HPLC. Our results indicate that there is an age\u2010dependent strain\u2010specific expression of methionine cycle genes in the mouse cochlea and a further regulation during the response to noise damage. Loss of\n                    <jats:italic>Bhmt<\/jats:italic>\n                    did not cause an evident impact in the hearing acuity of young mice, but it produced higher threshold shifts and poorer recovery following noise challenge. Hearing loss was associated with increased cochlear injury, outer hair cell loss, altered expression of cochlear methionine cycle genes, and hyperhomocysteinemia. Our results suggest that BHMT plays a central role in the homeostasis of cochlear methionine metabolism and that\n                    <jats:italic>Bhmt2<\/jats:italic>\n                    up\u2010regulation could carry out a compensatory role in cochlear protection against noise injury in the absence of BHMT.\u2014Partearroyo, T., Murillo\u2010Cuesta, S., Vallecillo, N., Berm\u00fadez\u2010Mu\u00f1oz, J. M., Rodr\u00edguez\u2010de la Rosa, L., Mandruzzato, G., Celaya, A. M., Zeisel, S. H., Pajares, M. A., Varela\u2010Moreiras, G., Varela\u2010Nieto, I. Betaine\u2010homocysteine\n                    <jats:italic>S<\/jats:italic>\n                    \u2010methyltransferase deficiency causes increased susceptibility to noise\u2010induced hearing loss associated with plasma hyperhomocysteinemia. FASEB J. 33, 5942\u20135956 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801533r","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T16:28:52Z","timestamp":1549988932000},"page":"5942-5956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Betaine\u2010homocysteine\n                    <i>S<\/i>\n                    \u2010methyltransferase deficiency causes increased susceptibility to noise\u2010induced hearing loss associated with plasma hyperhomocysteinemia"],"prefix":"10.1096","volume":"33","author":[{"given":"Teresa","family":"Partearroyo","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas y de la Salud Facultad de Farmacia Universidad Centro de Estudios Universitarios CEU 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Enfermedades Raras, (CIBERER) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Paz (IdiPAZ)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Mandruzzato","sequence":"additional","affiliation":[{"name":"Research and development MED\u2010EL  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaida M.","family":"Celaya","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Alberto Sols Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Aut\u00f3noma de Madrid (CSIC\u2010UAM)  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras, (CIBERER) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Zeisel","sequence":"additional","affiliation":[{"name":"Nutrition Research Institute 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