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Our previous studies have shown that muscle\u2010derived stem\/progenitor cell (MDSPC) function is significantly enhanced in MRL\/MpJ mice when compared with MDSPCs isolated from age\u2010matched wild\u2010type (WT) mice. Using mass spectrometry\u2013based proteomic analysis, we identified increased expression of hypoxia\u2010inducible factor (HIF) 1\u03b1 target genes (expression of glycolytic factors and antioxidants) in sera from MRL\/MpJ mice compared with WT mice. Therefore, we hypothesized that HIF\u20101\u03b1 promotes the high muscle healing capacity of MRL\/MpJ mice by increasing the potency of MDSPCs. We demonstrated that treating MRL\/MpJ MDSPCs with dimethyloxalylglycine and CoCl\n                    <jats:sub>2<\/jats:sub>\n                    increased the expression of HIF\u20101\u03b1 and target genes, including angiogenic and cell survival genes. We also observed that HIF\u20101\u03b1 activated the expression of paired box (Pax)7 through direct interaction with the\n                    <jats:italic>Pax7<\/jats:italic>\n                    promoter. Furthermore, we also observed a higher myogenic potential of MDSPCs derived from prolyl hydroxylase (Phd) 3\u2014knockout (\n                    <jats:italic>\n                      Phd3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    ) mice, which displayed higher stability of HIF\u20101\u03b1. Taken together, our findings suggest that HIF\u20101\u03b1 is a major determinant in the increased MDSPC function of MRL\/MpJ mice through enhancement of cell survival, proliferation, and myogenic differentiation.\u2014Sinha, K. M., Tseng, C., Guo, P., Lu, A., Pan, H., Gao, X., Andrews, R., Eltzschig, H., Huard, J. Hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1) is a major determinant in the enhanced function of muscle\u2010derived progenitors from MRL\/MpJ mice. FASEB J. 33, 8321\u20138334 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801794r","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T17:55:26Z","timestamp":1554918926000},"page":"8321-8334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1) is a major determinant in the enhanced function of muscle\u2010derived progenitors from MRL\/MpJ mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Krishna M.","family":"Sinha","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery McGovern Medical School University of Texas Health Science Center\u2013Houston  Houston Texas 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