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In AC, T helper type 2 (T\n                    <jats:sub>h<\/jats:sub>\n                    2) immune responses play central roles in orchestrating inflammatory responses. However, the roles of lipid mediators in the onset and progression of AC remain to be fully explored. Although previous reports have shown the beneficial effects of supplementation of \u03c9\u20103 fatty acids in asthma or atopic dermatitis, the underlying molecular mechanisms are poorly understood. In this study, a diet rich in \u03c9\u20103 fatty acids alleviated AC symptoms in both early and late phases without affecting T\n                    <jats:sub>h<\/jats:sub>\n                    2 immune responses, but rather by altering the lipid mediator profiles. The \u03c9\u20103 fatty acids completely suppressed scratching behavior toward the eyes, an allergic reaction provoked by itch. Although total serum IgE levels and the expression levels of T\n                    <jats:sub>h<\/jats:sub>\n                    2 cytokines and chemokines in the conjunctiva were not altered by \u03c9\u20103 fatty acids, eosinophil infiltration into the conjunctiva was dramatically suppressed. The levels of \u03c9\u20106\u2013derived proinflammatory lipid mediators, including those with chemoattractant properties for eosinophils, were markedly reduced in the conjunctivae of \u03c9\u20103 diet\u2013fed mice. Dietary \u03c9\u20103 fatty acids can alleviate a variety of symptoms of AC by altering the lipid mediator profile.\u2014Hirakata, T., Lee, H.\u2010C., Ohba, M., Saeki, K., Okuno, T., Murakami, A., Matsuda, A., Yokomizo, T. Dietary \u03c9\u20103 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T\n                    <jats:sub>h<\/jats:sub>\n                    2 immune responses. FASEB J. 33, 3392\u20133403 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801805r","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T16:39:38Z","timestamp":1541090378000},"page":"3392-3403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Dietary \u03c9\u20103 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T\n                    <sub>h<\/sub>\n                    2 immune responses"],"prefix":"10.1096","volume":"33","author":[{"given":"Toshiaki","family":"Hirakata","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"},{"name":"Department of Biochemistry Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Cheol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Ohba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Yokomizo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Juntendo University Graduate School of Medicine  Bunkyo-ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.050"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.042"},{"key":"e_1_2_8_4_1","first-page":"149","article-title":"Updates in the treatment of ocular allergies","volume":"3","author":"Kari O.","year":"2010","journal-title":"J. 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