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Epidemiologic studies suggest that moderate alcohol consumption is beneficial for cognitive function, but they do not show the ingredients in alcoholic beverages. Previously, we reported that long\u2010term consumption of IAAs prevents inflammation and Alzheimer pathologies in mice, but their effects on cognitive function have not been evaluated. In the present study, we demonstrated that the consumption of IAAs improves spatial and object recognition memory functions not only in normal Crl:CD1(ICR) male mice but also in mice with pharmacologically induced amnesia. IAA consumption increased the total and extracellular levels of dopamine in the hippocampus of mice and Sprague\u2010Dawley male rats, respectively. Dopamine D\n                    <jats:sub>1<\/jats:sub>\n                    receptor antagonist treatment and knockdown of dopamine D\n                    <jats:sub>1<\/jats:sub>\n                    receptor expression in the hippocampus attenuated IAA\u2010induced spatial memory improvement. Furthermore, vagotomy attenuated the effects of IAAs in improving spatial and object recognition memory functions and increasing the total level of dopamine in the hippocampus. These results suggest that the consumption of IAAs activates dopamine receptor\u2014signaling in the hippocampus in a vagus nerve\u2014dependent manner and, consequently, improves spatial and object recognition memory functions. Vagal activation with food components including IAAs may be an easy and safe approach to improve cognitive functions.\u2014Ano, Y., Hoshi, A., Ayabe, T., Ohya, R., Uchida, S., Yamada, K., Kondo, K., Kitaoka, S., Furuyashiki, T. Iso\u2010\u03b1\u2010acids, the bitter components of beer, improve hippocampus\u2010dependent memory through vagus nerve activation. 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