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The striatin protein family, which are part of the striatin interaction phosphatases and kinases complex, are multidomain scaffolding proteins that play important biologic roles. We have previously shown that striatin colocalizes with the tumor suppressor protein adenomatous polyposis coli in the TJs of epithelial cells. Here we show that striatin affects junction integrity and cell migration, probably through a mechanism that involves the adhesion molecule E\u2010cadherin. Cells engaged in cell\u2014cell adhesion expressed a high MW\u2010modified form of striatin that forms stable associations with detergent\u2010insoluble, membrane\u2010bound cellular fractions. In addition, striatin has recently been suggested to be a target of the poly (ADP\u2010ribose) polymerases Tankyrase 1, and we have found that striatin interacts with Tankyrase 1 and is subsequently poly\u2010ADP\u2010ribosylated. Taken together, our results suggest that striatin is a novel cell\u2014cell junctional protein that functions to maintain correct cell adhesion and may have a role in establishing the relationship between AJs and TJs that is fundamental for epithelial cell\u2014cell adhesion.\u2014Lahav\u2010Ariel, L., Caspi, M., Nadar\u2010Ponniah, P. T., Zelikson, N., Hofmann, I., Hanson, K. K., Franke, W. W., Sklan, E. H., Avraham, K. B., Rosin\u2010Arbesfeld, R. Striatin is a novel modulator of cell adhesion. FASEB J. 33, 4729\u20134740 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801882r","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T14:39:12Z","timestamp":1546007952000},"page":"4729-4740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Striatin is a novel modulator of cell adhesion"],"prefix":"10.1096","volume":"33","author":[{"given":"Lital","family":"Lahav\u2010Ariel","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Immunology Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Caspi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and 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