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In this study, a statistical approach, coimmunoprecipitation, and immunofluorescence staining have been used to confirm that S246\u2192Y and S246\u2192W missense mutations, which help increase the ICPB in Xaa246\u2010P247 (Xaa is any amino acid) in human \u03b2\u2010catenin, can reduce the interactions between \u03b2\u2010catenin and adenomatous polyposis coli (APC) and between \u03b2\u2010catenin and Ca2\n                    <jats:sup>+<\/jats:sup>\n                    \u2010dependent cell adhesion molecule family in epithelial tissue (E\u2010cadherin), eventually leading to increased nuclear migration of \u03b2\u2010catenin in the HepG2 cell line (an immortalized cell line consisting of human liver carcinoma cells). Conversely, S246\u2192L and S246\u2192M missense mutations, which reduce the ICPB in Xaa246\u2010P247 in human \u03b2\u2010catenin, can enhance interactions between \u03b2\u2010catenin and APC and between \u03b2\u2010catenin and E\u2010cadherin, leading to decreased nuclear migration of \u03b2\u2010catenin. These results not only indicate that a change in the ICPB may be an important cause of functional protein changes but also provide a new basis for the study of genetic disease prediction, gene diagnosis, individualized treatment, and protein modification at the gene level for clinicians and other professionals.\u2014Yu, S., Zhang, Y., Wu, Y., Yang, H., Chen, Y., Yang, Y., Zhang, Z. Subcellular localization of mutated \u03b2\u2010catenins with different incidences of\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010peptide bonds at the Xaa246\u2010P247 site in HepG2 cells. FASEB J. 33, 6574\u20136583 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801937rr","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T18:46:37Z","timestamp":1551206797000},"page":"6574-6583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Subcellular localization of mutated \u03b2\u2010catenins with different incidences of\n                    <i>cis<\/i>\n                    \u2010peptide bonds at the Xaa246\u2010P247 site in HepG2 cells"],"prefix":"10.1096","volume":"33","author":[{"given":"Shuhui","family":"Yu","sequence":"first","affiliation":[{"name":"School of Life Sciences Chongqing University  Chongqing China"},{"name":"Information Institute of Southwest University Southwest University  Chongqing 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