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Here we generated primordial germ cell\u2013specific\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    knockout (c\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice to elucidate the effects of\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    on spermatogenesis. We demonstrated that\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    deficiency results in infertility in male mice due to impaired spermatogenesis. We found that c\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibited smaller size of testes as well as lower sperm concentration and motility than the wild\u2010type mice. Mechanistically, we demonstrated that\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    deficiency in primordial germ cells induced elevated levels of reactive oxygen species, mitochondria dysfunction, apoptosis, and loss of stemness of spermatogonial stem cells (SSCs) in testes. In\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    \u2010deficienct SSCs, elevated oxidative stress and mitochondrial dysfunction could be partially reversed by treatment with the antioxidant\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine (NAC), whereas NAC treatment did not restore the fertility or ameliorate the apoptosis caused by loss of\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    . Overall, our findings provided new insights into understanding the crucial role of\n                    <jats:italic>Xrcc1<\/jats:italic>\n                    during spermatogenesis.\u2014Xu, C., Xu, J., Ji, G., Liu, Q., Shao, W., Chen, Y., Gu, J., Weng, Z., Zhang, X., Wang, Y., Gu, A. Deficiency of X\u2010ray repair cross\u2010complementing group 1 in primordial germ cells contributes to male infertility. FASEB J. 33, 7427\u20137436 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801962rr","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T14:01:03Z","timestamp":1555596063000},"page":"7427-7436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Deficiency of X\u2010ray repair cross\u2010complementing group 1 in primordial germ cells contributes to male infertility"],"prefix":"10.1096","volume":"33","author":[{"given":"Cheng","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine Institute of Toxicology Nanjing Medical University Nanjing China"},{"name":"Key Laboratory of Modern Toxicology Ministry of Education School of Public Health Nanjing Medical University Nanjing 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