{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:08:35Z","timestamp":1790723315649,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK 56260"],"award-info":[{"award-number":["DK 56260"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK 52574"],"award-info":[{"award-number":["DK 52574"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL 38180"],"award-info":[{"award-number":["HL 38180"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["DK 068437"],"award-info":[{"award-number":["DK 068437"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["DK 101251"],"award-info":[{"award-number":["DK 101251"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Liver fatty acid binding protein (L\u2010Fabp) modulates lipid trafficking in enterocytes, hepatocytes, and hepatic stellate cells (HSCs). We examined hepatocyte\n                    <jats:italic>vs<\/jats:italic>\n                    . HSC\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    deletion in hepatic metabolic adaptation and fibrotic injury. Floxed\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    mice were bred to different transgenic Cre mice or injected with adeno\u2010associated virus type 8 (AAV8) Cre and fed diets to promote steatosis and fibrosis or were subjected to either bile duct ligation or CCl\n                    <jats:sub>4<\/jats:sub>\n                    injury. Albumin\u2010Cre\u2010mediated\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    deletion revealed recombination in hepatocytes and HSCs; these findings were confirmed with 2 other floxed alleles. Glial fibrillary acid protein\u2010Cre and platelet\u2010derived growth factor receptor \u03b2\u2010Cre\u2010mediated\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    deletion demonstrated recombination only in HSCs. Mice with albumin promoter\u2010driven Cre recombinase (Alb\u2010Cre)\u2010mediated or AAV8\u2010mediated\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    deletion were protected against food withdrawal\u2010induced steatosis. Mice with Alb\u2010Cre\u2010mediated\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    deletion were protected against high saturated fat\u2010induced steatosis and fibrosis, phenocopying germline\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Mice with HSC\u2010specific\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    deletion exhibited retinyl ester depletion yet demonstrated no alterations in fibrosis. On the other hand, fibrogenic resolution after CCl\n                    <jats:sub>4<\/jats:sub>\n                    administration was impaired in mice with Alb\u2010Cre\u2010mediated\n                    <jats:italic>L\u2010Fabp<\/jats:italic>\n                    deletion. These findings suggest cell type\u2010specific roles for L\u2010Fabp in mitigating hepatic steatosis and in modulating fibrogenic injury and reversal.\u2014Newberry, E. P., Xie, Y., Lodeiro, C., Solis, R., Moritz, W., Kennedy, S., Barron, L., Onufer, E., Alpini, G., Zhou, T., Blaner, W. S., Chen, A., Davidson, N. O. Hepatocyte and stellate cell deletion of liver fatty acid binding protein reveal distinct roles in fibrogenic injury. FASEB J. 33, 4610\u20134625 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801976r","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T16:25:14Z","timestamp":1545409514000},"page":"4610-4625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hepatocyte and stellate cell deletion of liver fatty acid binding protein reveals distinct roles in fibrogenic injury"],"prefix":"10.1096","volume":"33","author":[{"given":"Elizabeth P.","family":"Newberry","sequence":"first","affiliation":[{"name":"Gastroenterology Division Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lodeiro","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Solis","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Moritz","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Barron","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Division Department of Surgery Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Onufer","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Division Department of Surgery Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Alpini","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Texas A&amp;M University  Temple Texas USA"},{"name":"Department of Internal Medicine Texas A&amp;M University  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Texas A&amp;M University  Temple Texas USA"},{"name":"Department of Internal Medicine Texas A&amp;M University  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Blaner","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Saint Louis University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas O.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29845"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","unstructured":"Greuter T. Malhi H. Gores G. J. andShah V. H.(2017)Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis.JCI Insight2 pii: 95354","DOI":"10.1172\/jci.insight.95354"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.053"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27645"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.209551"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.01.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000057"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04573.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05294.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27409"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.328708"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.06.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26318"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309377200"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21369"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.02.031"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M046342"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-9-14"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28941"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.034"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.1.305"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20384"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29138"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00418.2010"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27606"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0115"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-0002-4"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M020966"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00170.2015"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800645-JLR200"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/jn\/138.10.1859","article-title":"Liver fatty acid-binding protein geneablated female mice exhibit increased age-dependent obesity","volume":"138","author":"Martin G. G.","year":"2008","journal-title":"J. Nutr."},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050296"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M077487"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M029801"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22473"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-013-9532-5"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/252387"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.170233"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59261"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29371"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30474-4"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M063412"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00446"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.02.002"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.87336"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04584.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201840109"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201801976R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201801976R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201801976R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:47:09Z","timestamp":1761673629000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201801976R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1096\/fj.201801976R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201801976r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,21]]},"assertion":[{"value":"2018-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}