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Here, we found that the macrolide antibiotic brefeldin A (BFA) exhibits considerable antitumor activity both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Induction of complete autophagic flux is characterized as a key event in BFA\u2010induced CRC suppression. Mechanistically, BFA provokes endoplasmic reticulum stress\u2010mediated binding immunoglobulin protein (Bip) expression, leading to increased Bip\/Akt interaction and resultant decreased Akt phosphorylation, thereby activating autophagy. Autophagy inhibition or Bip suppression relieves BFA\u2010induced cell death, suggesting a key role for Bip\u2010regulated autophagy in the antitumor properties of BFA. Moreover, BFA acts synergistically with paclitaxel or 5\u2010fluorouracil in CRC suppression. Collectively, our study provides an important molecular basis for BFA\u2010induced autophagy and suggests that the antibiotic BFA could be repositioned as a potential anticancer drug for CRC treatment.\u2014Zhou, L., Gao, W., Wang, K., Huang, Z., Zhang, L., Zhang, Z., Zhou, J., Nice, E. C., Huang, C. Brefeldin A inhibits colorectal cancer growth by triggering Bip\/Akt\u2010regulated autophagy. FASEB J. 33, 5520\u20135534 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801983r","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T18:29:08Z","timestamp":1548181748000},"page":"5520-5534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Brefeldin A inhibits colorectal cancer growth by triggering Bip\/Akt\u2010regulated autophagy"],"prefix":"10.1096","volume":"33","author":[{"given":"Li","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"},{"name":"West China School of Basic Sciences and Forensic Medicine Sichuan University  Chengdu China"},{"name":"Department of Oncology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"},{"name":"West China School of Basic Sciences and Forensic Medicine Sichuan University  Chengdu China"},{"name":"Department of Oncology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"},{"name":"West China School of Basic Sciences and Forensic Medicine Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard C.","family":"Nice","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhua","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital  Chengdu China"},{"name":"West China School of Basic Sciences and Forensic Medicine Sichuan University  Chengdu China"},{"name":"Department of Oncology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21286"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3735"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.22"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.02.049"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.53"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.10.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311909"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.21.160"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90517-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/15658"},{"key":"e_1_2_8_15_1","first-page":"52","article-title":"Antiproliferative effect in vitro and antitumor activity in vivo of brefeldin A","volume":"2","author":"Sausville E. 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