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It was previously shown that, whereas NIH3T3 mouse fibroblasts expressing high levels of the yes\u2010associated protein 1(YAP1) target TEA domain family (TEAD) transcription factors become \u201cwinners\u201d in cell competitions, Madin\u2010Darby canine kidney cells expressing activated YAP1 become \u201closers\u201d and are eliminated from culture monolayers. Thus, YAPl's role in cell competitions is clearly context dependent. Here, we show that keratinocytes overexpressing a constitutively activated YAP1 mutant lose in\n                    <jats:italic>in vitro<\/jats:italic>\n                    competitions with control cells conducted in standard tissue culture dishes and undergo apical extrusion. Similarly, cells in which endogenous YAP1 is activated by\n                    <jats:italic>NF2<\/jats:italic>\n                    knockdown become losers. The YAP1\u2010overexpressing cells exhibit a decrease in cell\u2010matrix adhesion because of defective expression of adhesion molecules such as fibronectin\u20101. Cell adhesion\u2010mediated proliferation is also impaired. However, because of intrinsic factors, YAP1\u2010expressing cells proliferate faster than control cells when cocultured in dishes impeding cell adhesion.\n                    <jats:italic>In vivo, Mob1a<\/jats:italic>\n                    \/\n                    <jats:italic>b<\/jats:italic>\n                    \u2010deficient (YAP1\u2010activated) epidermis, which shows decreased expression of type XVII collagen, cannot be engrafted successfully onto donor mice. YAP1\u2010activated skin grafts shrink away from surrounding control skin, and the epidermis peels off the basement membrane. Our data show that YAP1 activation controls cell competition in part by decreasing cell adhesion.\u2014Nishio, M., Miyachi, Y., Otani, J., Tane, S., Omori, H., Ueda, F., Togashi, H., Sasaki, T., Mak, T. W., Nakao, K., Fujita, Y., Nishina, H., Maehama, T., Suzuki, A. Hippo pathway controls cell adhesion and context\u2010dependent cell competition to influence skin engraftment efficiency. FASEB J. 33, 5548\u20135560 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802005r","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T15:38:17Z","timestamp":1547480297000},"page":"5548-5560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hippo pathway controls cell adhesion and context\u2010dependent cell competition to influence skin engraftment efficiency"],"prefix":"10.1096","volume":"33","author":[{"given":"Miki","family":"Nishio","sequence":"first","affiliation":[{"name":"Division of Molecular and Cellular Biology Department of Biochemistry and Molecular Biology Kobe University Graduate School of Medicine Kobe University  Kobe Japan"},{"name":"Division of Cancer Genetics Department of Molecular Genetics 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