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Rodent studies have demonstrated that hypervitaminosis A increases cortical bone resorption, whereas the importance of the effects on bone formation is less well defined. We used an experimental model of increased bone formation by loading of the tibiae to investigate the effect of vitamin A on bone formation. Control [retinol activity equivalents (RAE) 4.5 \u00b5g\/g chow] or vitamin A (RAE 60 \u00b5g\/g chow) diets were given to female C57BL\/6N mice for 4 wk, after which the tibiae were subjected to axial loading on alternate days for 2 wk, while the diets were continued. Vitamin A inhibited the loading\u2010induced increase in trabecular and cortical bone volume. This was attributed to inhibition of loading\u2010induced increase in osteoblast number and activity, and expression of osteoblastic genes\n                    <jats:italic>Sp7, Alpl<\/jats:italic>\n                    , and\n                    <jats:italic>Col1a1<\/jats:italic>\n                    in cortical bone. Vitamin A., loading, and combination thereof also resulted in site\u2010specific effects on bone composition measured by Raman spectroscopy. In summary, a clinically relevant dose of vitamin A suppresses the loading\u2010induced gain of bone mass by decreasing bone formation. These observations may have implications for regulation of bone mass caused by physical activity and the risk of osteoporosis in humans.\u2014Lionikaite, V., Henning, P., Drevinge, C., Shah, F. A., Palmquist, A., Wikstr\u00f6m, P., Windahl, S. H., Lerner, U. H. Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation. FASEB J. 33, 5237\u20135247 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802040r","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T18:36:15Z","timestamp":1548182175000},"page":"5237-5247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation"],"prefix":"10.1096","volume":"33","author":[{"given":"Vikte","family":"Lionikaite","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Centre for Bone and Arthritis Research Institute for Medicine  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Henning","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Centre for Bone and Arthritis Research Institute for Medicine  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Drevinge","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Centre for Bone and Arthritis Research Institute for Medicine  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furqan A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Palmquist","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medical Bioscience, Pathology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara H.","family":"Windahl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Centre for Bone and Arthritis Research Institute for Medicine  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf H.","family":"Lerner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Centre for Bone and Arthritis Research Institute for Medicine  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2013.215"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","article-title":"Cellular and molecular mechanisms of bone remodeling. 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