{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:12:32Z","timestamp":1777417952149,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010909","name":"Young Scientists Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012069","name":"Hoyu Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008731","name":"Nakatomi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although prostaglandins (PGs) are known to be involved in the progression of arthritis, the role of PGD\n                    <jats:sub>2<\/jats:sub>\n                    remains unclear. In this study, we evaluated the role of PGD\n                    <jats:sub>2<\/jats:sub>\n                    in joint inflammation using genetically modified mice. Injection of complete Freund's adjuvant (CFA) increased the production of PGD\n                    <jats:sub>2<\/jats:sub>\n                    and induced paw swelling and cartilage erosion in wild\u2010type (WT) mice. These phenomena were accompanied with an increase in the mRNA levels of TNF\u2010\u03b1, IL\u20106, IL\u20101\u03b2, and matrix\u2010degrading metalloproteinase\u20109. Knockdown of hematopoietic PGD synthase (H\u2010PGDS) abolished the PGD\n                    <jats:sub>2<\/jats:sub>\n                    production and exacerbated all of the arthritic manifestations in the inflamed paw. Immunostaining revealed that infiltrating macrophages strongly expressed H\u2010PGDS in the CFA\u2010injected paw. Morphologic studies revealed vascular hyperpermeability and angiogenesis in the inflamed WT paw. H\u2010PGDS deficiency was accelerated, whereas daily administration of a PGD\n                    <jats:sub>2<\/jats:sub>\n                    receptor D prostanoid (DP) agonist attenuated the CFA\u2010induced hyperpermeability and angiogenesis. We further confirmed that DP deficiency exacerbated, whereas the administration of the DP agonist improved, the CFA\u2010induced arthritic manifestations. The findings demonstrate that H\u2010PGDS\u2013derived PGD\n                    <jats:sub>2<\/jats:sub>\n                    ameliorates joint inflammation by attenuating vascular permeability and subsequent angiogenesis and indicates the therapeutic potential of a DP agonist for arthritis.\u2014Tsubosaka, Y., Maehara, T., Imai, D., Nakamura, T., Kobayashi, K., Nagata, N., Fujii, W., Murata, T. Hematopoietic prostaglandin D synthase\u2013derived prostaglandin D\n                    <jats:sub>2<\/jats:sub>\n                    ameliorates adjuvant\u2010induced joint inflammation in mice. FASEB J. 33, 6829\u20136837 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802153r","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T17:12:35Z","timestamp":1551287555000},"page":"6829-6837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hematopoietic prostaglandin D synthase\u2013derived prostaglandin D\n                    <sub>2<\/sub>\n                    ameliorates adjuvant\u2010induced joint inflammation in mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Yoshiki","family":"Tsubosaka","sequence":"first","affiliation":[{"name":"Department of Animal Radiology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Department of Animal Radiology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Animal Radiology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Animal Radiology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Animal Radiology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanae","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Animal Radiology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Applied Genetics Graduate School of Agriculture and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Animal Radiology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.4.321"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11176"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S3470"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.13.2089"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.10.036"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0559"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009747709095440"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199809)41:9<1591::AID-ART9>3.0.CO;2-J"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051310"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215528"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0021-9258(19)40239-1","article-title":"Mast cells contain spleen-type prostaglandin D synthetase","volume":"265","author":"Urade Y.","year":"1990","journal-title":"J. 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