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Here, gene arrays revealed that\n                    <jats:italic>H. diminuta<\/jats:italic>\n                    antigen (HdAg) evoked a program in murine macrophages distinct from that elicited by IL\u20104. Further, HdAg suppressed LPS\u2010evoked release of TNF\u2010\u03b1 and IL\u20101\u03b2 from macrophages\n                    <jats:italic>via<\/jats:italic>\n                    autocrine IL\u201010 signaling. In assessing the ability of macrophages treated\n                    <jats:italic>in vitro<\/jats:italic>\n                    with an extract of\n                    <jats:italic>H. diminuta<\/jats:italic>\n                    [M\n                    <jats:sup>(HdAg)<\/jats:sup>\n                    ] to affect disease, intravenous, but not peritoneal, injection of M\n                    <jats:sup>(HdAg)<\/jats:sup>\n                    protected wild\u2010type but not\n                    <jats:italic>RAG1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice from dinitrobenzene sulphonic acid (DNBS)\u2010induced colitis. Administration of splenic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from\n                    <jats:italic>in vitro<\/jats:italic>\n                    cocultures with M\n                    <jats:sup>(HdAg)<\/jats:sup>\n                    , but not those cocultured with M\n                    <jats:sup>(IL\u20104)<\/jats:sup>\n                    cells, inhibited DNBS\u2010induced colitis; fractionation of the T\u2010cell population indicated that the CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    T cells from cocultures with M\n                    <jats:sup>(HdAg)<\/jats:sup>\n                    drove the suppression of DNBS\u2010induced colitis. Use of IL\u20104\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    or IL\u201010\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells revealed that neither cytokine alone from the donor cells was essential for the anticolitic effect. These data illustrate that HdAg evokes a unique regulatory program in macrophages, identifies HdAg\u2010evoked IL\u201010 suppression of macrophage activation, and reveals the ability of HdAg\u2010treated macrophages to educate (\n                    <jats:italic>i.e<\/jats:italic>\n                    ., condition) and mobilize CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    T cells, which could be deployed to treat colonic inflammation.\u2014Reyes, J. L., Lopes, F., Leung, G., Jayme, T. S., Matisz, C. E., Shute, A., Burkhard, R., Carneiro, M., Workentine, M. L., Wang, A., Petri, B., Beck, P. L., Geuking, M. B., McKay, D. M., Macrophages treated with antigen from the tapeworm\n                    <jats:italic>Hymenolepis diminuta<\/jats:italic>\n                    condition CD25\n                    <jats:sup>+<\/jats:sup>\n                    T cells to suppress colitis. FASEB J. 33, 5676\u20135689 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802160r","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T18:56:17Z","timestamp":1548183377000},"page":"5676-5689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Macrophages treated with antigen from the tapeworm\n                    <i>Hymenolepis diminuta<\/i>\n                    condition CD25\n                    <sup>+<\/sup>\n                    T cells to suppress colitis"],"prefix":"10.1096","volume":"33","author":[{"given":"Jos\u00e9 L.","family":"Reyes","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology University of Calgary  Alberta Canada"},{"name":"Laboratorio de Inmunolog\u00eda Experimental y Regulaci\u00f3n de la Inflamaci\u00f3n Hepato\u2010Intestinal Unidad de Investigaci\u00f3n en Biomedicina (UBIMED) Facultad de Estudios Superiores (FES) Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Tlalnepantla de Baz M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Calgary  Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Calgary  Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy S.","family":"Jayme","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Calgary  Alberta 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