{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:37:42Z","timestamp":1788388662563,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/"}],"funder":[{"DOI":"10.13039\/501100009573","name":"People's Liberation Army University of Science and Technology","doi-asserted-by":"publisher","award":["AWS14C003"],"award-info":[{"award-number":["AWS14C003"]}],"id":[{"id":"10.13039\/501100009573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011786","name":"Chongqing Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","award":["CSTC2016SHMSZX130068"],"award-info":[{"award-number":["CSTC2016SHMSZX130068"]}],"id":[{"id":"10.13039\/501100011786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Skeletal homeostasis is closely effectuated by the regulation of bone formation and bone resorption. Osteoclasts are multinuclear giant cells responsible for bone resorption. Overactivated osteoclasts and excessive bone resorption result in various lytic bone diseases, such as osteoporosis, osteoarthritis, periprosthetic infection, and inflammatory aseptic loosening of orthopedic implants. In consideration of the severe side effects caused by the currently available drugs, exploitation of novel drugs has gradually attracted attention. Because of its antiinflammatory, antioxidant, and antitumor capacities, diallyl disulfide (DADS), a major oil\u2010soluble organosulfur ingredient compound derived from garlic, has been widely researched. However, the effects of DADS on osteoclasts and lytic bone diseases are still unknown. In this study, we investigated the effects of DADS on receptor activator of NF\u2010\u03baB ligand (RANKL)\u2010 and LPS\u2010mediated osteoclastogenesis, LPS\u2010stimulated proinflammatory cytokines related to osteoclasts, and LPS\u2010induced inflammatory osteolysis. The results showed that DADS significantly inhibited RANKL\u2010mediated osteoclast formation, fusion, and bone resorption in a dose\u2010dependent manner\n                    <jats:italic>via<\/jats:italic>\n                    inhibiting the NF\u2010\u03baB and signal transducer and activator of transcription 3 signaling and restraining the interaction of NF\u2010\u03baB p65 with nuclear factor of activated T cells cytoplasmic 1. Furthermore, DADS also markedly suppressed LPS\u2010induced osteoclastogenesis and reduced the production of proinflammatory cytokines with LPS stimulation to indirectly mediate osteoclast formation. Consistent with the\n                    <jats:italic>in vitro<\/jats:italic>\n                    results, DADS prevented the LPS\u2010induced severe bone loss by blocking the osteoclastogenesis. All of the results indicate that DADS may be a potential and exploitable drug used for preventing and impeding osteolytic lesions.\u2014Yang, J., Tang, R., Yi, J., Chen, Y., Li, X., Yu, T., Fei, J. Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis\n                    <jats:italic>via<\/jats:italic>\n                    NF\u2010\u03baB\u2013NFATc1 signal pathway. FASEB J. 33, 7261\u20137273 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802172r","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T23:04:57Z","timestamp":1552345497000},"page":"7261-7273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis\n                    <i>via<\/i>\n                    NF\u2010\u03baB\u2013NFATc1 signal pathway"],"prefix":"10.1096","volume":"33","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[{"name":"Center of Trauma Daping Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohui","family":"Tang","sequence":"additional","affiliation":[{"name":"Center of Trauma Daping Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yi","sequence":"additional","affiliation":[{"name":"Center of Trauma Daping Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Guizhou Provincial People's Hospital Guizhou Medical University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fei","sequence":"additional","affiliation":[{"name":"Center of Trauma Daping Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00052-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2448"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0038"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.11.076"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.52.1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226179"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.5940"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1279"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130174"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135414"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.09.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.7.4858"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523394"},{"key":"e_1_2_8_18_1","article-title":"Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-\u03baB, ERK and JNK signaling pathways","volume":"7","author":"Feng W.","year":"2017","journal-title":"Sci. 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