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In this study, we further investigated the molecular mechanisms underlying adolescent cocaine exposure\u2010related psychiatric problems in adulthood, especially focusing on the alterations of GABAergic transmission in prelimbic cortex (PrL), 1 subregion of mPFC. Consistent with a previous study, adolescent cocaine\u2010exposed mice exhibited enhanced anxiety\u2010like behaviors in their adulthood. In the same mice models, depression\u2010like behaviors increased as well, but the conditioned place preference formed normally. In parallel, activities of pyramidal neurons at layer V of PrL were reduced after adolescent cocaine exposure, accompanied by an increase in the percentage of symmetric synapses in PrL of adult mice. Additionally, miniature inhibitory postsynaptic currents rather than miniature excitatory postsynaptic currents were increased on these pyramidal neurons, and increased levels of GABA were found in adult PrL. The molecules in the GABAergic system in adult PrL were also changed by adolescent cocaine use, as indicated by increased glutamate decarboxylase 67kDa, GAB A\n                    <jats:sub>A<\/jats:sub>\n                    \u2010\u03b1l, and decreased GABA transporter 1. In the same mice, some regulators to GABAergic transmission such as neuregulin l\/ErbB4 signals were heightened as well. Collectively, these findings revealed that adolescent cocaine exposure results in permanent enhancement of GABAergic transmission on pyramidal neurons in PrL, which subsequently attenuate the activities of these neurons and ultimately contributes to the development of psychiatric disorders in later life.\u2014Shi, P., Nie, J., Liu, H., Li, Y., Lu, X., Shen, X., Ge, F., Yuan, T.\u2010F., Guan, X. Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice. FASEB J. 33, 8614\u20138622 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802192rr","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T17:53:03Z","timestamp":1556560383000},"page":"8614-8622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Pengbo","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Histoembryology School of Medicine and Life Sciences Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxun","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histoembryology School of Medicine and Life Sciences Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychology School of Psychology Nanjing Normal University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histoembryology School of Medicine and Life Sciences Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histoembryology School of Medicine and Life Sciences Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histoembryology School of Medicine and Life Sciences Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histoembryology School of Medicine and Life Sciences Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ti-Fei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histoembryology School of Medicine and Life Sciences Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.6.1041"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11030489"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.01.030"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.03.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.11.041"},{"key":"e_1_2_8_7_1","first-page":"1829","article-title":"Adolescent cocaine exposure induces prolonged synaptic modifications in medial prefrontal cortex of adult rats","volume":"223","author":"Zhu W.","year":"2018","journal-title":"Brain Struct. 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