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This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast\u2010derived mesenchymal stem cells (MCA\u2010MSCs) with the corticosteroid dexamethasone (Dex) in experimental chronic AAD\/asthma. Female BALB\/c mice subjected to 11 wk of ovalbumin (Ova)\u2010induced chronic AAD were intranasally administered MCA\u2010MSCs (1 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    cells\/mouse; once weekly on wk 10 and 11), Dex (0.5 mg\/ml; once daily for 2 wk), or both combined. MCA\u2010MSC detection and changes in airway inflammation (AI), AWR, and airway hyper\u2010responsiveness (AHR) were measured at the end of wk 11. Mice with chronic AAD had significant AI, goblet cell metaplasia, epithelial damage\/thickening, aberrant TGF\u2010\u03b21 levels, subepithelial myofibroblast accumulation, airway\/lung fibrosis, and AHR (all\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.001 vs. healthy controls). MCA\u2010MSCs were detected in the lungs up to 5\u20137 d postadministration and demonstrated modest anti\u2010inflammatory but striking antifibrotic effects against Ova\u2010induced AAD, effectively decreasing AHR by 70\u201375% (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05\n                    <jats:italic>vs<\/jats:italic>\n                    . Ova alone). In comparison, Dex predominantly demonstrated anti\u2010inflammatory effects, decreasing AHR by \u223c30%. Combining MCA\u2010MSCs with Dex provided equivalent protection to that offered by either therapy alone. MCA\u2010MSCs reduce chronic AAD\u2010induced AWR and AHR to a greater extent than Dex and may act as a suitable adjunct therapy to corticosteroid treatment of asthma.\u2014Royce, S. G., Mao, W., Lim, R., Kelly, K., Samuel, C. S. iPSC\u2010 and mesenchymoangioblast\u2010derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid. FASEB J. 33, 6402\u20136411 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802307r","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T14:50:08Z","timestamp":1550242208000},"page":"6402-6411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["iPSC\u2010 and mesenchymoangioblast\u2010derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid"],"prefix":"10.1096","volume":"33","author":[{"given":"Simon G.","family":"Royce","sequence":"first","affiliation":[{"name":"Monash Biomedicine Discovery Institute Monash University  Clayton Victoria Australia"},{"name":"Department of Pharmacology Monash University  Clayton Victoria Australia"},{"name":"Central Clinical School Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyi","family":"Mao","sequence":"additional","affiliation":[{"name":"Monash Biomedicine Discovery Institute Monash University  Clayton Victoria Australia"},{"name":"Department of Pharmacology Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Lim","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research Department of Obstetrics and Gynecology Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kilian","family":"Kelly","sequence":"additional","affiliation":[{"name":"Cynata Therapeutics  Carlton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrishan S.","family":"Samuel","sequence":"additional","affiliation":[{"name":"Monash Biomedicine Discovery Institute Monash University  Clayton Victoria Australia"},{"name":"Department of Pharmacology Monash University  Clayton Victoria Australia"},{"name":"Department of Biochemistry and Molecular Biology The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2005.00509.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00526.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02971.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090474"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.10.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.15"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01620.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001913"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/318029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01216.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.8.771"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700178R"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.10.72"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2010.06.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.03.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0008OC"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13494"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945008784533561"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.140120"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2015.09.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160328"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2005.00256.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1975.55.3.418"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(95)48033-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","unstructured":"Murphy S. 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