{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:07:12Z","timestamp":1785928032147,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We hypothesized that low\u2010intensity endurance exercise might be more effective in preventing cancer cachexia\u2013induced muscle atrophy through both an increase in protein synthesis and a decrease in protein degradation. The purpose of present study was to evaluate the effects and to clarify the mechanism of low\u2010intensity endurance exercise on cancer cachexia\u2013induced muscle atrophy. Twenty\u2010four male Wistar rats were randomly divided into 4 groups: control (Cont), Cont plus exercise (Ex), AH130\u2010induced cancer cachexia (AH130), and AH130 plus Ex. Cancer cachexia was induced by intraperitoneal injections with AH130 Yoshida ascites hepatoma cells; we analyzed the changes in muscle mass and the gene and protein expression levels of major regulators or indicators of skeletal muscle protein degradation and synthesis pathway in the soleus muscles. Low\u2010intensity exercise inhibited the muscle mass loss through a suppression of the ubiquitin\u2010proteasome pathway, increased hypoxia\u2010inducible factor\u20101\u03b1 and phosphorylated AMPK, and inhibited the deactivation of mammalian target of rapamycin pathway in the soleus muscle, which contributed to the prevention of cancer cachexia\u2013induced muscle atrophy. These results suggest that low\u2010intensity exercise has the potential to become an effective therapeutic intervention for the prevention of cancer cachexia\u2013induced muscle atrophy.\u2014Tanaka, M., Sugimoto, K., Fujimoto, T., Xie, K., Takahashi, T., Akasaka, H., Kurinami, H., Yasunobe, Y., Matsumoto, T., Fujino, H., Rakugi, H. Preventive effects of low\u2010intensity exercise on cancer cachexia\u2013induced muscle atrophy. FASEB J. 33, 7852\u20137862 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802430r","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T12:27:40Z","timestamp":1553689660000},"page":"7852-7862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Preventive effects of low\u2010intensity exercise on cancer cachexia\u2013induced muscle atrophy"],"prefix":"10.1096","volume":"33","author":[{"given":"Minoru","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Department of Rehabilitation Science Kobe University Graduate School of Health Sciences  Kobe Japan"},{"name":"Department of Rehabilitation Science Osaka Health Science University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Department of Rehabilitation Science Osaka Health Science University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimasa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Kurinami","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Yasunobe","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Science Kobe University Graduate School of Health Sciences  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Science Kobe University Graduate School of Health Sciences  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Rakugi","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000165004.93707.88"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283347e77"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00054.2002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00410.2012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00579.2003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0049-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961127)68:5<637::AID-IJC14>3.0.CO;2-Z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024650"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3629"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00125.2012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.286740"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12931-014-0156-4","article-title":"Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats","volume":"15","author":"Qi Y.","year":"2014","journal-title":"Respir. Res."},{"key":"e_1_2_8_14_1","first-page":"94","article-title":"Muscle atrophy in patients with type 2 Diabetes Mellitus: roles of inflammatory pathways, physical activity and exercise","volume":"22","author":"Perry B. D.","year":"2016","journal-title":"Exerc. Immunol. Rev."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00354.2009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1139\/H09-042"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00528.2001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.20463\/jenb.2017.0022","article-title":"Low-intensity aerobic exercise training: inhibition of skeletal muscle atrophy in high-fat-diet-induced ovariectomized rats","volume":"21","author":"Km H. J.","year":"2017","journal-title":"J. Exerc. Nutrition Biochem."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0067-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2410153"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24316"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"42323","DOI":"10.1038\/srep42323","article-title":"Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice","volume":"7","author":"Takeshita H.","year":"2017","journal-title":"Sci. Rep."},{"key":"e_1_2_8_24_1","first-page":"152","article-title":"Preventive effects of kilohertz frequency electrical stimulation on sepsis-induced muscle atrophy","volume":"16","author":"Tanaka M.","year":"2016","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1152\/jappl.1992.73.2.776","article-title":"Expression of muscle capillary alkaline phosphatase is affected by hypoxia","volume":"73","author":"Hansen-Smith F. M.","year":"1992","journal-title":"J. Appl. Physiol. (1985)"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2016016"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-012-9473-4"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2014.06.009"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600167"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00105-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.020"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00400-3"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00090.2016"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00166-06"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700968R"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.02.019"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(94)90223-2"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-196154"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0748-0"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3389\/fphys.2017.00856","article-title":"Short-term high- and moderate-intensity training modifies inflammatory and metabolic factors in response to acute exercise","volume":"8","author":"Lira F. S.","year":"2017","journal-title":"Front. Physiol."},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.biocel.2016.01.011","article-title":"TNF-\u03b1 induces vascular endothelial cells apoptosis through overexpressing pregnancy induced noncoding RNA in Kawasaki disease model","volume":"72","author":"Jiang C.","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.109942"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.012"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1119"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000163633.10240.3b"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06905"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.019"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.11.014"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.265.2.E275"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00126.2010"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00410.2011"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201802430R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201802430R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201802430R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:19:49Z","timestamp":1761689989000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201802430R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1096\/fj.201802430R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201802430r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]},"assertion":[{"value":"2018-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}