{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:30:30Z","timestamp":1778599830860,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01688"],"award-info":[{"award-number":["PI17\/01688"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic lymphocytic leukemia (CLL) is characterized by a failure in the mechanisms of apoptosis that leads to an accumulation of mature B cells in peripheral blood, bone marrow, and lymphoid organs. The molecular basis of CLL remains unknown. Certain cytogenetic and molecular markers determine a bad prognosis in CLL. Fanconi anemia complementation (FANC) proteins have been related to chromosomal instability and alterations in the mechanisms of p53 activation, control of cell cycle, and apoptosis. We investigated the role of certain FANC proteins in CLL. Our data identified a group of patients with CLL with high expression of\n                    <jats:italic>FANCA<\/jats:italic>\n                    in peripheral B\u2010CLL cells and we established its relationship with the deletion of 11q23 and a worse prognosis. When we investigated the molecular mechanisms of this bad prognosis, we observed a reduction in the expression of 2 p53 target genes,\n                    <jats:italic>p<\/jats:italic>\n                    21 and \u0394\n                    <jats:italic>Np73<\/jats:italic>\n                    , in CLL primary cells transfected with\n                    <jats:italic>FANCA<\/jats:italic>\n                    . Functional studies demonstrated an impairment of p53 by FANCA. Moreover, we obtained evidence of a cooperation between FANCA and the NEDD8\u2013interacting protein NUB1L in the destabilization of p53. For the first time,\n                    <jats:italic>FANCA<\/jats:italic>\n                    is reported as a bad prognosis marker by a mechanism other than its role in the Fanconi anemia\u2013breast cancer DNA repair pathway.\u2014Bravo\u2010Navas, S., Y\u00e1\u00f1ez, L., Rom\u00f3n, \u00cd., Pipa\u00f3n, C. Elevated\n                    <jats:italic>FANCA<\/jats:italic>\n                    expression determines a worse prognosis in chronic lymphocytic leukemia and interferes with p53 function. FASEB J. 33,10477\u201310489 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802439rr","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T09:49:02Z","timestamp":1561715342000},"page":"10477-10489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elevated\n                    <i>FANCA<\/i>\n                    expression determines a worse prognosis in chronic lymphocytic leukemia and interferes with p53 function"],"prefix":"10.1096","volume":"33","author":[{"given":"Sara","family":"Bravo\u2010Navas","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL) Hospital Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrecia","family":"Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL) Hospital Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00cd\u00f1igo","family":"Rom\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL) Hospital Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"And Carlos","family":"Pipa\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL) Hospital Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.96"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1250264"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29566"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-772285"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.03.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-10-0559"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.07.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00747-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-011-0645-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.07.038"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.492"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1038\/jid.2011.181","article-title":"Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non\u2010melanoma skin cancer","volume":"131","author":"Kao W. 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