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Major spliceosome defects are implicated in male infertility; however, the underlying mechanistic links between the spliceosome and the ribosome in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    testes remains largely unresolved. Small ribonucleoprotein particle protein SmD3 (SmD3) is a novel germline stem cell (GSC) regulatory gene identified in our previous screen of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    testes. In the present study, using genetic manipulation in a\n                    <jats:italic>Drosophila<\/jats:italic>\n                    model, we demonstrated that SmD3 is required for the GSC niche and controls the self\u2010renewal and differentiation of GSCs in the testis. Using\n                    <jats:italic>in vitro<\/jats:italic>\n                    assays in Schneider 2 cells, we showed that SmD3 also regulates the homeostasis of proliferation and apoptosis in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . Furthermore, using liquid chromatography\u2013tandem mass spectrometry methods, SmD3 was identified as binding with ribosomal protein (Rp)L18, which is a key regulator of the large subunit in the ribosome. Moreover, SmD3 was observed to regulate spliceosome and ribosome subunit expression levels and controlled spliceosome and ribosome function\n                    <jats:italic>via<\/jats:italic>\n                    RpL18. Significantly, our findings revealed the genetic causes and molecular mechanisms underlying the stem cell niche and the crosstalk between the spliceosome and the ribosome.\u2014Yu, J., Luan, X., Yan, Y., Qiao, C, Liu, Y., Zhao, D., Xie, B., Zheng, Q., Wang, M., Chen, W., Shen, C, He, Z., Hu, X., Huang, X., Li, H., Chen, B., Zheng, B., Chen, X., Fang, J. Small ribonucleoprotein particle protein SmD3 governs the homeostasis of germline stem cells and the crosstalk between the spliceosome and ribosome signals in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . FASEB J. 33, 8125\u20138137 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201802536rr","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T19:37:05Z","timestamp":1553801825000},"page":"8125-8137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Small ribonucleoprotein particle protein SmD3 governs the homeostasis of germline stem cells and the crosstalk between the spliceosome and ribosome signals in\n                    <i>Drosophila<\/i>"],"prefix":"10.1096","volume":"33","author":[{"given":"Jun","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Gynecology Jiangsu University  Zhenjiang China"},{"name":"Reproductive Sciences Institute Jiangsu University  Zhenjiang 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Nanjing Medical University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Reproductive Sciences Institute Jiangsu University  Zhenjiang China"},{"name":"Center for Reproduction  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Jiangsu University The Fourth People's Hospital of Zhenjiang  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gynecology Jiangsu University  Zhenjiang China"},{"name":"Reproductive Sciences Institute Jiangsu University  Zhenjiang 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