{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:31:05Z","timestamp":1761669065017,"version":"build-2065373602"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01\u2010HD\u2010068777","R01\u2010HD\u2010042311"],"award-info":[{"award-number":["R01\u2010HD\u2010068777","R01\u2010HD\u2010042311"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A nonreceptive uterus is a major cause of embryo implantation failure. This study examined the importance of the G\u03b1\n                    <jats:sub>q\/11<\/jats:sub>\n                    \u2010coupled class of GPCRs as regulators of uterine receptivity. Mice were created lacking uterine G\u03b1\n                    <jats:sub>q<\/jats:sub>\n                    and G\u03b1\n                    <jats:sub>11<\/jats:sub>\n                    ; as a result, signaling by all uterine G\u03b1\n                    <jats:sub>q\/11<\/jats:sub>\n                    \u2010coupled receptors was disrupted. Reproductive profiling of the knockout females revealed that on d 4 of pregnancy, despite adequate serum progesterone (P4) levels and normal P4 receptor (PR) expression, there was no evidence of PR signaling. This resulted in the down\u2010regulation of heart and neural crest derivatives expressed 2, Kruppel\u2010like factor 15, and cyclin G1 and the subsequent persistent proliferation of the luminal epithelium. Aquaporin (Aqp) 11 was also potently down\u2010regulated, whereas\n                    <jats:italic>A\u03b7p5<\/jats:italic>\n                    \/AQP5 expression persisted, resulting in the inhibition of luminal closure. Hypertrophy of the myometrial longitudinal muscle was also dramatically diminished, likely contributing to the observed implantation failure. Further analyses revealed that a major mechanism\n                    <jats:italic>via<\/jats:italic>\n                    which uterine G\u03b1\n                    <jats:sub>q\/11<\/jats:sub>\n                    signaling induces PR signaling is through the transcriptional up\u2010regulation of leucine\u2010rich repeat\u2010containing GPCR 4 (\n                    <jats:italic>Lgr4<\/jats:italic>\n                    ). LGR4 was previously identified as a trigger of PR activation and signaling. Overall, this study establishes that G\u03b1\n                    <jats:sub>q\/11<\/jats:sub>\n                    signaling, in a P4\u2010dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse, and disruption of such signaling results in P4 resistance.\u2014de Oliveira, V., Schaefer, J., Calder, M., Lydon, J. P., DeMayo, F. J., Bhattacharya, M., Radovick, S., Babwah, A. V. Uterine G\u03b1\n                    <jats:sub>q\/11<\/jats:sub>\n                    signaling, in a progesterone\u2010dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse. FASEB J. 33, 9374\u20139387 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900026r","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T18:55:15Z","timestamp":1557946515000},"page":"9374-9387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Uterine G\u03b1\n                    <sub>q\/11<\/sub>\n                    signaling, in a progesterone\u2010dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse"],"prefix":"10.1096","volume":"33","author":[{"given":"Vanessa","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Pediatrics Rutgers University  New Brunswick New Jersey USA"},{"name":"Child Health Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rutgers University  New Brunswick New Jersey USA"},{"name":"Child Health Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Calder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Lydon","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco J.","family":"Demayo","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Biology Laboratory The National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshmi","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Medicine Robert Wood Johnson Medical School Rutgers University  New Brunswick New Jersey USA"},{"name":"Child Health Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Radovick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rutgers University  New Brunswick New Jersey USA"},{"name":"Child Health Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy V.","family":"Babwah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rutgers University  New Brunswick New Jersey USA"},{"name":"Child Health Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"U.S. Department of Health and Human Services Office on Women's Health.Infertility. 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