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However, the role of LKB1 in cartilaginous tumorigenesis is still poorly understood. In this study, we find that cartilage\u2010specific, tamoxifen\u2010inducible\n                    <jats:italic>Lkb1<\/jats:italic>\n                    knockout results in multiple enchondroma\u2010like lesions adjacent to the disorganized growth plates. We showed that chondrocytes retain an immature status caused by loss of\n                    <jats:italic>Lkb1<\/jats:italic>\n                    , which may lead to the dramatic expansion of growth\u2010plate cartilage and the formation of enchondroma\u2010like lesions. Additionally, increased mammalian target of rapamycin complex 1 (mTORC1) activity is observed in the\n                    <jats:italic>Lkb1<\/jats:italic>\n                    conditional knockout (cKO) chondrocytes, and rapamycin (mTORC1 inhibitor) treatment significantly alleviates the expansion of growth\u2010plate cartilage and eliminates the enchondroma\u2010like lesions in\n                    <jats:italic>Lkb1<\/jats:italic>\n                    cKO mice. Thus, our findings indicate that loss of\n                    <jats:italic>Lkb1<\/jats:italic>\n                    leads to the expansion of chondrocytes and the formation of enchondroma\u2010like lesions during postnatal cartilage development, and that the up\u2010regulated mTORC1\u2010signaling pathway is implicated in this process. Our findings suggest that modulation of LKB1 and related signaling is a potential therapy in cartilaginous tumorigenesis.\u2014Zhou, S., Li, Y., Qiao, L., Ge, Y., Huang, X., Gao, X., Ju, H., Wang, W., Zhang, J., Yan, J., Teng, H., Jiang, Q. Inactivation of\n                    <jats:italic>Lkb1<\/jats:italic>\n                    in postnatal chondrocytes leads to epiphyseal growth\u2010plate abnormalities and promotes enchondroma\u2010like formation. FASEB J. 33,9476\u20139488 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900294rr","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T19:46:37Z","timestamp":1557949597000},"page":"9476-9488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inactivation of\n                    <i>Lkb1<\/i>\n                    in postnatal chondrocytes leads to epiphyseal growth\u2010plate abnormalities and promotes enchondroma\u2010like formation"],"prefix":"10.1096","volume":"33","author":[{"given":"Sheng","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive Surgery Nanjing Drum Tower Hospital The Affiliated Hospital 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