{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:35:30Z","timestamp":1791916530817,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2015\u201065786\u2010R"],"award-info":[{"award-number":["SAF2015\u201065786\u2010R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    The main objective of this work was to investigate whether mitochondrial fusion occurs in the skeletal muscle of well\u2010trained athletes in response to high\u2010intensity exercise. Well\u2010trained swimmers (\n                    <jats:italic>n<\/jats:italic>\n                    = 9) performed a duration\u2010matched sprint interval training (SIT) and high\u2010intensity high\u2010volume training (HIHVT) session on separate days. Muscle samples from triceps brachii were taken before, immediately after, and 3 h after the training sessions. Transmission electron microscopy (TEM) was applied to assess mitochondrial morphology. Moreover, expression of genes coding for regulators of mitochondrial fusion and fission were assessed by real\u2010time quantitative PCR. In addition, mitofusin (MFN)2 and optic atrophy 1 (OPA1) were quantified by Western blot analysis. TEM analyses showed that mitochondrial morphology remained altered for 3 h after HIHVT, whereas SIT\u2010induced changes were only evident immediately after exercise. Only SIT increased MFN1 and MFN2 mRNA expression, whereas SIT and HIHVT both increased MFN2 protein content 3 h after exercise. Notably, only HIHVT increased OPA1 protein content. Mitochondrial morphologic changes that suggest fusion occurs in well\u2010adapted athletes during exercise. However, HIHVT appears as a more robust inducer of mitochondrial fusion events than SIT. Indeed, SIT induces a rapid and transient change in mitochondrial morphology.\u2014Huertas, J. R., Ruiz\u2010Ojeda, F. J., Plaza\u2010D\u00edaz, J., Nordsborg, N. B., Mart\u00edn\u2010Albo, J., Rueda\u2010Robles, A., Casuso, R. A. Human muscular mitochondrial fusion in athletes during exercise. FASEB J. 33, 12087\u201012098 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900365rr","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T18:12:53Z","timestamp":1565374373000},"page":"12087-12098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Human muscular mitochondrial fusion in athletes during exercise"],"prefix":"10.1096","volume":"33","author":[{"given":"Jes\u00fas R.","family":"Huertas","sequence":"first","affiliation":[{"name":"Department of Physiology School of Pharmacy University of Granada Granada Spain"},{"name":"Jos\u00e9 Mataix Institute of Nutrition and Food Technology, Biomedical Research Centre University of Granada Granada 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Biosanitaria de Granada (IBS.GRANADA) Complejo Hospitalario Universitario de Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai B.","family":"Nordsborg","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise, and Sports (NEXS), Section of Integrative Physiology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mart\u00edn\u2010Albo","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Mataix Institute of Nutrition and Food Technology, Biomedical Research Centre University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ascensi\u00f3n","family":"Rueda\u2010Robles","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Mataix Institute of Nutrition and Food Technology, Biomedical Research Centre University of Granada Granada 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