{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:56:39Z","timestamp":1792684599672,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    The major side effect of tacrolimus (Tac) is nephrotoxicity. We studied whether supplementation of coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    , (CoQ\n                    <jats:sub>10<\/jats:sub>\n                    ) a potent antioxidant, can reduce Tac\u2010induced nephrotoxicity\n                    <jats:italic>via<\/jats:italic>\n                    improving mitochondrial function. In an\n                    <jats:italic>in vitro<\/jats:italic>\n                    study, CoQ\n                    <jats:sub>10<\/jats:sub>\n                    reduced the production of Tac\u2010induced mitochondrial reactive oxygen species and abolished the loss of mitochondrial membrane potential in proximal tubular cell line. Assessment of mitochondrial function revealed that CoQ\n                    <jats:sub>10<\/jats:sub>\n                    decreased oxygen consumption and mitochondrial respiration rate increased by Tac, suggesting improvement of mitochondrial function to synthesize ATP with CoQ\n                    <jats:sub>10<\/jats:sub>\n                    treatment. The effect of the CoQ\n                    <jats:sub>10<\/jats:sub>\n                    <jats:italic>in vitro<\/jats:italic>\n                    study was observed in an experimental model of chronic Tac\u2010induced nephropathy. CoQ\n                    <jats:sub>10<\/jats:sub>\n                    attenuated Tac\u2010induced oxidative stress and was accompanied by function and histologic improvement. On electron microscopy, addition of CoQ\n                    <jats:sub>10<\/jats:sub>\n                    increased not only the number but also the volume of mitochondria compared with Tac treatment only. Our data indicate that CoQ\n                    <jats:sub>10<\/jats:sub>\n                    improves Tac\u2010induced mitochondrial dysfunction in kidney. Supplementary CoQ\n                    <jats:sub>10<\/jats:sub>\n                    treatment may be a promising approach to reduce Tac\u2010induced nephrotoxicity.\u2014Yu, J. H., Lim, S. W., Luo, K., Cui, S., Quan, Y., Shin, Y. J., Lee, K. E., Kim, H. L., Ko, E. J., Chung, B. H., Kim, J. H., Chung, S. J., Yang, C. W. Coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    alleviates tacrolimus\u2010induced mitochondrial dysfunction in kidney. FASEB J. 33, 12288\u201012298 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900386rr","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T21:19:53Z","timestamp":1566335993000},"page":"12288-12298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Coenzyme Q\n                    <sub>10<\/sub>\n                    alleviates tacrolimus\u2010induced mitochondrial dysfunction in kidney"],"prefix":"10.1096","volume":"33","author":[{"given":"Ji Hyun","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine The Catholic University of Korea School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Woo","family":"Lim","sequence":"additional","affiliation":[{"name":"Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital The Catholic University of Korea School of Medicine Seoul South Korea"},{"name":"Transplant Research Center The Catholic University of Korea School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Luo","sequence":"additional","affiliation":[{"name":"Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital The Catholic University of Korea School of Medicine Seoul South Korea"},{"name":"Transplant Research Center The Catholic University of Korea School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Cui","sequence":"additional","affiliation":[{"name":"Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital The Catholic University of Korea School of Medicine Seoul South 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Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Advanced Analysis Center Korea Institute of Science and Technology Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Lim","family":"Kim","sequence":"additional","affiliation":[{"name":"Integrative Research Support Center The Catholic University of Korea School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jeong","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Catholic University of Korea School of Medicine Seoul South Korea"},{"name":"Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital The Catholic University of Korea School of Medicine Seoul South Korea"},{"name":"Transplant Research Center The Catholic University of Korea School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung 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