{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:45:26Z","timestamp":1788050726334,"version":"build-2784847793"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802223,81702214,81802843,81802222,81572111,81772318"],"award-info":[{"award-number":["81802223,81702214,81802843,81802222,81572111,81772318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Wear debris\u2010induced osteolysis and ensuing aseptic loosening is the main cause of implant failure and revision surgery. Wear debris\u2010induced inflammatory response plays key roles in peri\u2010implant osteolysis. Recently, substantial of evidence suggests that hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), the third gasotransmitter, is a critical player regulating inflammation. However, the role and therapeutic potential of H\n                    <jats:sub>2<\/jats:sub>\n                    S in wear debris\u2010induced inflammation and osteolysis remains to be defined. In the present study, we investigated the effect of H\n                    <jats:sub>2<\/jats:sub>\n                    S on wear debris\u2010induced pro\u2010inflammatory cytokines expression and osteolysis in vitro and in vivo. With a slow\u2010releasing H\n                    <jats:sub>2<\/jats:sub>\n                    S donor GYY4137, our study demonstrated that H\n                    <jats:sub>2<\/jats:sub>\n                    S attenuated wear debris\u2010induced osteolysis and osteoclastogenesis in murine calvaria resorption models. The expression of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20101\u03b2 (IL\u20101\u03b2), and interleukin\u20106 (IL\u20106) that stimulated by wear particles were significantly reduced by GYY4137. Further, the level of sirtuin 1 (SIRT1), which possesses anti\u2010inflammation property, was examined in vivo and in macrophages. And we found that wear debris decreased the expression of SIRT1. Cotreated macrophages with GYY4137 in part reversed the decline of SIRT1. More importantly, with the SIRT1 recombinant lentivirus and small interfering RNAs (siRNA) against SIRT1, our data indicated that SIRT1 mediated the inhibitory effects of GYY4137 on wear debris\u2010induced inflammation. Collectively, these results suggested that exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S production (via H\n                    <jats:sub>2<\/jats:sub>\n                    S donors) may represent a potential approach for the treatment of wear particle\u2010induced osteolysis.\n                  <\/jats:p>","DOI":"10.1096\/fj.201900393rr","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T05:55:20Z","timestamp":1578981320000},"page":"3743-3754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Hydrogen sulfide protects against particle\u2010induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening"],"prefix":"10.1096","volume":"34","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University Soochow 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