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We previously shown that exposure of rd10 mutant mice, modeling autosomal recessive RP, to environmental enrichment (EE), with enhanced motor, sensorial and social stimuli, results into a sensible delay of retinal degeneration and vision loss. Searching for effectors of EE\u2010mediated retinal protection, we performed transcriptome analysis of the retina of rd10 enriched and control mice and found that gene expression at the peaks of rod and cone degeneration is characterized by a strong inflammatory\/immune response, which is however measurably lower in enrichment conditions. Treating rd10 mice with dexamethasone during the period of maximum photoreceptors death lowered retinal inflammation and caused a preservation of cones and cone\u2010mediated vision. Our findings indicate a link between retinal inflammation and bystander cone degeneration, reinforcing the notion that cone vision in RP can be preserved using anti\u2010inflammatory approaches.\u2014Guadagni, V., Biagioni, M., Novelli, E., Aretini, P., Mazzanti, C. M., Strettoi, E. Rescuing cones and daylight vision in retinitis pigmentosa mice. FASEB J. 33, 10177\u201310192 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900414r","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T17:07:05Z","timestamp":1560532025000},"page":"10177-10192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Rescuing cones and daylight vision in retinitis pigmentosa mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Viviana","family":"Guadagni","sequence":"first","affiliation":[{"name":"Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Biagioni","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Novelli","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Aretini","sequence":"additional","affiliation":[{"name":"Laboratory of Genomics and Transcriptomics Fondazione Pisana per la Scienza  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Maria","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"Laboratory of Genomics and Transcriptomics Fondazione Pisana per la Scienza  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Strettoi","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.2.151"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2717"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-012-2555-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.08.004"},{"key":"e_1_2_8_6_1","first-page":"1545","article-title":"Long\u2010term preservation of cone photoreceptors and visual acuity in rd10 mutant mice exposed to continuous environmental enrichment","volume":"20","author":"Barone I.","year":"2014","journal-title":"Mol. 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