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However, the regulation and function of BHLHE40 in\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic>H pylori<\/jats:italic>\n                    )\u2010associated gastritis is unknown. We observed that gastric BHLHE40 was significantly elevated in patients and mice with\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection. Then, we demonstrate that\n                    <jats:italic>H pylori\u2010<\/jats:italic>\n                    infected GECs express BHLHE40 via\n                    <jats:italic>cagA<\/jats:italic>\n                    \u2010ERK pathway. BHLHE40 translocates to cell nucleus, and then binds to\n                    <jats:italic>cagA<\/jats:italic>\n                    protein\n                    <jats:italic>\u2010<\/jats:italic>\n                    activated p\u2010STAT3 (Tyr705). The complex increases chemotactic factor CXCL12 expression (production). Release of CXCL12 from GECs fosters CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration in the gastric mucosa. Our results identify the\n                    <jats:italic>cagA<\/jats:italic>\n                    \u2010BHLHE40\u2010CXCL12 axis that contributes to inflammatory response in gastric mucosa during\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1096\/fj.201900464rr","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T08:18:03Z","timestamp":1575015483000},"page":"1169-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Upexpression of BHLHE40 in gastric epithelial cells increases CXCL12 production through interaction with p\u2010STAT3 in\n                    <i>Helicobacter pylori<\/i>\n                    \u2010associated gastritis"],"prefix":"10.1096","volume":"34","author":[{"given":"Yong\u2010Sheng","family":"Teng","sequence":"first","affiliation":[{"name":"National Engineering Research 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