{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:47:23Z","timestamp":1792799243727,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P12\u2010CTS\u20102722"],"award-info":[{"award-number":["P12\u2010CTS\u20102722"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["AGR\u20106826"],"award-info":[{"award-number":["AGR\u20106826"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS 164"],"award-info":[{"award-number":["CTS 164"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of the present study was to examine whether the immune\u2010modulatory bacteria\n                    <jats:italic>Lactobacillus fermentum<\/jats:italic>\n                    CECT5716 (LC40) ameliorates disease activity and cardiovascular complications in a female mouse model of lupus. Eighteen\u2010week\u2010old NZBWF1 [systemic lupus erythematosus (SLE)] and NZW\/LacJ (control) mice were treated with vehicle or LC40 (5 \u00d7 10\n                    <jats:sup>8<\/jats:sup>\n                    colony\u2010forming units\/d) for 15 wk. LC40 treatment reduced lupus disease activity, blood pressure, cardiac and renal hypertrophy, and splenomegaly in SLE mice. LC40 reduced the elevated T, B, regulatory T cells (T\n                    <jats:sub>reg<\/jats:sub>\n                    ), and T helper (T\n                    <jats:sub>h<\/jats:sub>\n                    )\u20101 cells in mesenteric lymph nodes of lupus mice. LC40 lowered the higher plasma concentration of proinflammatory cytokines observed in lupus mice. Aortas from SLE mice showed reduced endothelium\u2010dependent vasodilator responses to acetylcholine. Endothelial dysfunction found in SLE is related to an increase of both NADPH oxidase\u2010driven superoxide production and eNOS phosphorylation at the inhibitory Thr\n                    <jats:sup>495<\/jats:sup>\n                    . These activities returned to normal values after a treatment with LC40. Probiotic administration to SLE mice reduced plasma LPS levels, which might be related to an improvement of the gut barrier integrity. LC40 treatment increases the\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    count in gut microbiota of SLE mice. In conclusion, our findings identify the gut microbiota manipulation with LC40 as an alternative approach to the prevention of SLE and its associated vascular damage.\u2014Toral, M., Robles\u2010Vera, I., Romero, M., de la Visitaci\u00f3n, N., S\u00e1nchez, M., O'Valle, F., Rodriguez\u2010Nogales, A., G\u00e1lvez, J., Duarte, J., Jim\u00e9nez, R.\n                    <jats:italic>Lactobacillus fermentum<\/jats:italic>\n                    CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus. FASEB J. 33, 10005\u201310018 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900545rr","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T13:28:03Z","timestamp":1559914083000},"page":"10005-10018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["<i>Lactobacillus fermentum<\/i>\n                    CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus"],"prefix":"10.1096","volume":"33","author":[{"given":"Marta","family":"Toral","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Robles\u2010Vera","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs.GRANADA)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor","family":"de la Visitaci\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs.GRANADA)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"O'Valle","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs.GRANADA)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Rodriguez\u2010Nogales","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs.GRANADA)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"},{"name":"Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBER\u2010EHD) University of Granada  Granada Spain"},{"name":"Center for Biomedical Research (CIBM) University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs.GRANADA)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"},{"name":"Center for Biomedical Research (CIBM) University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs.GRANADA)  Granada Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovaculares (CIBERCV)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs.GRANADA)  Granada Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovaculares (CIBERCV)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308089988"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130874"},{"key":"e_1_2_8_4_1","first-page":"493","article-title":"Cardiovascular risk factor screening in systemic lupus erythematosus","volume":"30","author":"Al\u2010Herz A.","year":"2003","journal-title":"J. Rheumatol."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90864.2008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI87425"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01548-14"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000309"},{"key":"e_1_2_8_9_1","first-page":"e02288","article-title":"Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus","volume":"84","author":"Luo X. M.","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02676-14"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0300-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14223-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26819"},{"key":"e_1_2_8_14_1","first-page":"107","article-title":"Differences in the occurrence of hypertension among (NZB X NZW)F1, MRL\u2010lpr, and BXSB mice with lupus nephritis","volume":"116","author":"Rudofsky U. H.","year":"1984","journal-title":"Am. J. Pathol."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.05.085"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00168.2006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08655"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4390"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517002112"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.09.028"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0890334404272393"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500290"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"e1800033","DOI":"10.1002\/mnfr.201800033","article-title":"Lactobacillus fermentum improves tacrolimus\u2010induced hypertension by restoring vascular redox state and improving eNOS coupling","volume":"30","author":"Toral M.","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800298"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130339"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03587"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90992.2008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2359-2365.2006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.1.114-123.2002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.11.016"},{"key":"e_1_2_8_31_1","first-page":"458","article-title":"Pathogenicity and genetic variation of 3 strains of Corynebacterium bovis in immunodeficient mice","volume":"52","author":"Dole V. S.","year":"2013","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000080107"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.160"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01687"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv401"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00062-07"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00845-13"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05315"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i48.18316"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12327"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.115"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.13"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.006"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.10.010"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(88)90065-0"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.12.027"},{"key":"e_1_2_8_48_1","first-page":"430","article-title":"B lymphocyte activation in systemic lupus erythematosus: spontaneous production of IgG antibodies to DNA and environmental antigens in cultures of blood mononuclear cells","volume":"73","author":"Dar O.","year":"1988","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs422"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000160549.60980.a8"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.301087"},{"key":"e_1_2_8_52_1","first-page":"971","article-title":"Bacterial lipopolysaccharide transforms mesangial into proliferative lupus nephritis without interfering with processing of pathogenic immune complexes in NZB\/Wmice","volume":"137","author":"Cavallo T.","year":"1990","journal-title":"Am. J. Pathol."},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339400300614"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.4.G941"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11276"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4296"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<2017::AID-IMMU2017>3.0.CO;2-2"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39233"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04006"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/823085"},{"key":"e_1_2_8_61_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13075-017-1478-7","article-title":"Role of endoplasmic reticulum stress in the protective effects of PPAR\u03b2\/8 activation on endothelial dysfunction induced by plasma from patients with lupus","volume":"19","author":"Toral M.","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118872"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.00603"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00051.2012"},{"key":"e_1_2_8_65_1","first-page":"1308","article-title":"Roles of B cell\u2010intrinsic TLR signals in systemic lupus erythematosus","volume":"16","author":"Ma K.","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_8_66_1","first-page":"57","article-title":"Cytokines in the pathogenesis of systemic lupus erythematosus","volume":"19","author":"Kelley V. R.","year":"1999","journal-title":"Semin. Nephrol."}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201900545RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201900545RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201900545RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:29:10Z","timestamp":1761672550000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201900545RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,7]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1096\/fj.201900545RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.201900545rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,7]]},"assertion":[{"value":"2019-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}