{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:19:26Z","timestamp":1790403566916,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK072482"],"award-info":[{"award-number":["P30 DK072482"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    During endoplasmic reticulum (ER) stress conditions, an adaptive signaling network termed the unfolded protein response (UPR) is activated. The UPR's function is to increase ER protein\u2010folding capacity in order to attenuate ER stress, restore ER homeostasis, and, most importantly, promote cell survival. X\u2010box\u2013binding protein 1 (XBP1) is one component of the UPR and is a proadaptive transcription factor that is subject to transcriptional, post\u2010transcriptional, and post\u2010translational control. In the present study, we identified a post\u2010transcriptional mechanism mediated by\n                    <jats:italic>miR\u201034c\u20105p<\/jats:italic>\n                    that governs the expression of both the spliced (active) and unspliced (latent) forms of\n                    <jats:italic>XBP1<\/jats:italic>\n                    mRNAs. We showed that\n                    <jats:italic>miR\u201034c\u20105p<\/jats:italic>\n                    directly attenuates spliced XBP1 (\n                    <jats:italic>XBP1s<\/jats:italic>\n                    ) mRNA levels during ER stress and thus regulates the proadaptive component of the UPR that is mediated by XBP1s without interfering with the induction of apoptotic responses.\u2014Bartoszewska, S., Cabaj, A., Dabrowski, M., Collawn, J. F., Bartoszewski, R.\n                    <jats:italic>miR\u201034c\u20105p<\/jats:italic>\n                    modulates X\u2010box\u2010binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response. FASEB J. 33, 11541\u201311554 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900600rr","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T14:55:21Z","timestamp":1563375321000},"page":"11541-11554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["<i>miR\u201034c\u20105p<\/i>\n                    modulates X\u2010box\u2013binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response"],"prefix":"10.1096","volume":"33","author":[{"given":"Sylwia","family":"Bartoszewska","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Cabaj","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Nencki Institute of Experimental Biology Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"D\u0105browski","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Nencki Institute of Experimental Biology Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Collawn","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Bartoszewski","sequence":"additional","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.028"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201110131"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.074134"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"Karag\u00f6z G. E. Acosta-Alvear D. andWalter P.(2019)The unfolded protein response: detecting and responding to fluctuations in the protein-folding capacity of the endoplasmic reticulum.Cold Spring Harb. Perspect. Biol.a033886","DOI":"10.1101\/cshperspect.a033886"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00611-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602030200"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.964702"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.040584"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401373"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254312"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.038"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.664"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200310015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509868200"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11658-013-0106-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40139-014-0046-y","article-title":"Micrornas in ER stress: divergent roles in cell fate decisions","volume":"2","author":"Malhi H.","year":"2014","journal-title":"Cum Pathobiol. Rep."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1151"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20100193"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2449"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101293"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1197142"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06665-11"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201201077"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031518"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.096669"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.10.1.7507342"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385928-0.00001-8"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.304956"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-017-0054-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2017.10.001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-6-62"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"16431","DOI":"10.1038\/s41598-018-34861-2","article-title":"PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells","volume":"8","author":"Gebert M.","year":"2018","journal-title":"Sci. Rep."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092128"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135993"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2144\/000114450"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv216"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvh122"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bat069"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt328"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.035"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-92"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing","volume":"27","author":"Crimson A.","year":"2007","journal-title":"Mol. Cell"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201010055"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707610200"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.21.7448-7459.2003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.06.011"},{"key":"e_1_2_8_49_1","first-page":"134","article-title":"Role of p58IPK in endoplasmic reticulum stress-associated apoptosis and inflammation","volume":"9","author":"Boriushkin E.","year":"2014","journal-title":"J. Ophthalmic Vis. Res."},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.04.006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.040"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.06028"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509061200"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200508145"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23282"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0725-4"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115623109"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815767116"},{"key":"e_1_2_8_59_1","doi-asserted-by":"crossref","unstructured":"Sidrauski C. McGeachy A. M. Ingolia N. T. andWalter P.(2015)The small molecule ISRIB reverses the effects of eIF2\u03b1 phosphorylation on translation and stress granule assembly.Elife4","DOI":"10.7554\/eLife.05033"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11880"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11878"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05939"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1165804"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.449"},{"key":"e_1_2_8_65_1","first-page":"988","article-title":"XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma","volume":"40","author":"Sun Y.","year":"2018","journal-title":"Oncol. Rep."},{"key":"e_1_2_8_66_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbrc.2018.11.112","article-title":"XBP1-s promotes colorectal cancer cell proliferation by inhibiting TAp73 transcriptional activity","volume":"508","author":"Ji H.","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13119"},{"key":"e_1_2_8_68_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41467-018-08152-3","article-title":"IRE1\u03b1-XBP1s pathway promotes prostate cancer by activating c-MYC signaling","volume":"10","author":"Sheng X.","year":"2019","journal-title":"Nat. Commun."}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201900600RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201900600RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201900600RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:58:19Z","timestamp":1761681499000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201900600RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1096\/fj.201900600RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.201900600rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"assertion":[{"value":"2019-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}