{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:11:03Z","timestamp":1785391863737,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T00:00:00Z","timestamp":1565827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Abnormal placental development is one of the main etiological factors for intrauterine growth restriction (IUGR). Here, we show that LIN28A and LIN28B are significantly lower and lethal\u20107\n                    <jats:italic>(let\u20107)<\/jats:italic>\n                    microRNAs (miRNAs) significantly higher in term human IUGR vs. normal placentas. We hypothesize that\n                    <jats:italic>let\u20107<\/jats:italic>\n                    miRNAs regulate genes with known importance for human placental development [high\u2010mobility group AT\u2010hook 1\n                    <jats:italic>(HMGA1)<\/jats:italic>\n                    , transcriptional regulator Myc\u2010like\n                    <jats:italic>(c\u2010myc)<\/jats:italic>\n                    , vascular endothelial growth factor A (\n                    <jats:italic>VEGF\u2010A<\/jats:italic>\n                    ), and Wnt family member 1 (\n                    <jats:italic>WNT1<\/jats:italic>\n                    )] by targeting the AT\u2010rich interacting domain (ARID)\u20103B complex. ACH\u20103P cells with LIN28A and LIN28B knockout (DKOs) significantly increased\n                    <jats:italic>let\u20107<\/jats:italic>\n                    miRNAs, leading to significantly decreased ARID3A, ARID3B, and lysine demethylase 4C (KDM4C). Similarly, Sw.71 cells overexpressing LIN28A and LIN28B (DKIs) significantly decreased\n                    <jats:italic>let\u20107<\/jats:italic>\n                    miRNAs, leading to significantly increased ARID3A, ARID3B, and KDM4C. In ACH\u20103P cells, ARID3A, ARID3B, and KDM4C make a triprotein complex [triprotein complex comprising ARID3A, ARID3B, and KDM4C (ARID3B\u2010complex)] that binds the promoter regions of\n                    <jats:italic>HMGA1, c\u2010MYC<\/jats:italic>\n                    , VEGF\u2010A, and\n                    <jats:italic>WNT1<\/jats:italic>\n                    . ARID3B knockout in ACH\u20103P cells disrupted the ARID3B\u2010complex, leading to a significant decrease in HMGA1, c\u2010MYC, VEGF\u2010A, and WNT1. DKOs had a significant reduction, whereas DKIs had a significant increase in HMGA1, c\u2010MYC, VEGF\u2010A, and WNT1, potentially due to regulation by the ARID3B\u2010complex. This is the first study showing regulation of let\u20107 targets in immortalized human trophoblast cells by the ARID3B\u2010complex.\u2014Ali, A., Anthony, R. V., Bouma, G. J., Winger, Q. A. LIN28\n                    <jats:italic>\u2010let\u20107<\/jats:italic>\n                    axis regulates genes in immortalized human trophoblast cells by targeting the ARID3B\u2010complex. FASEB J. 33, 12348\u201312363 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900718rr","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T16:53:50Z","timestamp":1565888030000},"page":"12348-12363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["LIN28\u2010\n                    <i>let\u20107<\/i>\n                    axis regulates genes in immortalized human trophoblast cells by targeting the ARID3B\u2010complex"],"prefix":"10.1096","volume":"33","author":[{"given":"Asghar","family":"Ali","sequence":"first","affiliation":[{"name":"Animal Reproduction and Biotechnology Laboratory Department of Biomedical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell V.","family":"Anthony","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Biotechnology Laboratory Department of Biomedical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit J.","family":"Bouma","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Biotechnology Laboratory Department of Biomedical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinton A.","family":"Winger","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Biotechnology Laboratory Department of Biomedical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.12.059"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1152249"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981219"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1430"},{"key":"e_1_2_9_6_1","first-page":"217","article-title":"[Relation between placental morphometry and fetal growth]","volume":"27","author":"Yu K. 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