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Lipid profiling of\n                    <jats:italic>E3hom<\/jats:italic>\n                    TPs was conducted using chromatography and mass spectrometry. The analyses revealed that the lipid composition of\n                    <jats:italic>E3hom<\/jats:italic>\n                    TPs was strikingly different from that of their\n                    <jats:italic>E3wt<\/jats:italic>\n                    littermates. The mutation affected major classes of meibomian lipids \u2010 cholesteryl esters, wax esters, and cholesteryl esters of (\n                    <jats:italic>O<\/jats:italic>\n                    )\u2010acylated w\u2010hydroxy fatty acids. The studies illuminated the central role of ELOVL3 in producing C\n                    <jats:sub>21:0<\/jats:sub>\n                    \u2010C\n                    <jats:sub>29:0<\/jats:sub>\n                    fatty acids, including odd\u2010chain and branched ones. Ablation of ELOVL3 leads to selective changes in the lipid composition of meibum, making\n                    <jats:italic>E3hom<\/jats:italic>\n                    mice instrumental in studying the mechanisms of the biosynthesis of meibum and modeling various pathologies of human ocular surface and adnexa.\u2014Butovich, I. A., Wilkerson, A., Bhat, N., McMahon, A., Yuksel, S. On the pivotal role of\n                    <jats:italic>Elovl3<\/jats:italic>\n                    \/ELOVL3 in meibogenesis and ocular physiology of mice. FASEB J. 33, 10034\u201310048 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900725r","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T22:38:05Z","timestamp":1560811085000},"page":"10034-10048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["On the pivotal role of\n                    <i>Elovl3<\/i>\n                    \/ELOVL3 in meibogenesis and ocular physiology of mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Igor A.","family":"Butovich","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"The Graduate School of Biomedical Sciences University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Wilkerson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seher","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"522","article-title":"Meibomian gland studies: comparison of steer and human lipids","volume":"20","author":"Nicolaides N.","year":"1981","journal-title":"Invest. 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