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A protein kinase, receptor\u2010interacting protein (RIP)3, plays a crucial role in mediating different diseases. However, the role of RIP3 in macrophages in liver fibrosis has not yet been studied. In our study, we found that RIP3 expression was up\u2010regulated in liver tissues and macrophages of humans and mice with liver fibrosis. Absence of RIP3 in macrophages could alleviate inflammation and macrophage or neutrophil accumulation in mice after carbon tetrachloride (CCl4) or bile duct ligation (BDL) treatment. Importantly, RIP3 deficiency in macrophages could decrease CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced and BDL\u2010induced liver fibrosis in mice. Moreover, RIP3 deficiency could inhibit the TLR4\u2013NF\u2010\u03baB pathway through suppressing Rho\u2010associated coiled\u2010coil containing protein kinase (ROCK)l in macrophages. To explore the connection of ROCK1 and RIP3 in macrophages of mice with liver fibrosis\n                    <jats:italic>in vivo<\/jats:italic>\n                    , ROCK1\u2010overexpressed macrophages were infused to RIP3\u2010deficient mice, which resulted in increased inflammation and liver fibrosis. In conclusion, our findings suggest that RIP3 plays a crucial proinflammatory role in liver fibrosis by regulating the ROCK1\u2013TLR4\u2013NF\u2010\u03baB signaling pathway in macrophages and therefore may be a potential therapeutic target for immune\u2010mediated liver fibrosis.\u2014Wei, S., Zhou, H., Wang, Q., Zhou, S., Li, C, Liu, R., Qiu, J., Shi, C, Lu, L. RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1\u2010TLR4\u2010NF\u2010\u03baB pathway in macrophages. FASEB J. 33, 11180\u201311193 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900752r","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T15:02:23Z","timestamp":1562857343000},"page":"11180-11193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1\u2013TLR4\u2013NF\u2010\u03baB pathway in macrophages"],"prefix":"10.1096","volume":"33","author":[{"given":"Song","family":"Wei","sequence":"first","affiliation":[{"name":"School of Medicine Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hepatobiliary Center First Affiliated Hospital 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