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Although Glrx up\u2010regulation prevented endothelial cell (EC) migration and global Glrx transgenic mice had impaired ischemic vascularization, the effects of cell\u2010specific Glrx overexpression remained unknown. Here, we examined the role of EC\u2010specific Glrx up\u2010regulation in distinct models of angiogenesis; namely, hind limb ischemia and tumor angiogenesis. EC\u2010specific Glrx transgenic (EC\u2010Glrx TG) overexpression in mice significantly impaired EC migration in Matrigel implants and hind limb revascularization after femoral artery ligation. Additionally, ECs migrated less into subcutaneously implanted B16F0 melanoma tumors as assessed by decreased staining of EC markers. Despite reduced angiogenesis, EC\u2010Glrx TG mice unexpectedly developed larger tumors compared with control mice. EC\u2010Glrx TG mice showed higher levels of VEGF\u2010A in the tumors, indicating hypoxia, which may stimulate tumor cells to form vascular channels without EC, referred to as vasculogenic mimicry. These data suggest that impaired ischemic vascularization does not necessarily associate with suppression of tumor growth, and that antiangiogenic therapies may be ineffective for melanoma tumors because of their ability to implement vasculogenic mimicry during hypoxia.\u2014Yura, Y., Chong, B. S. H., Johnson, R. D., Watanabe, Y., Tsukahara, Y., Ferran, B., Murdoch, C. E., Behring, J. B., McComb, M. E., Costello, C. E., Janssen\u2010Heininger, Y. M. W., Cohen, R. A., Bachschmid, M. M., Matsui, R. Endothelial cell\u2010specific redox gene modulation inhibits angiogenesis but promotes B16F0 tumor growth in mice. FASEB J. 33, 14147\u201014158 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900786r","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T19:54:35Z","timestamp":1571946875000},"page":"14147-14158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Endothelial cell\u2010specific redox gene modulation inhibits angiogenesis but promotes B16F0 tumor growth in mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Yoshimitsu","family":"Yura","sequence":"first","affiliation":[{"name":"Department of Medicine, Vascular Biology Section Whitaker Cardiovascular Institute Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S. 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