{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:22:34Z","timestamp":1791498154027,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001832","name":"Radboud Universiteit","doi-asserted-by":"publisher","award":["RU DEC 2015-0112"],"award-info":[{"award-number":["RU DEC 2015-0112"]}],"id":[{"id":"10.13039\/501100001832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Proton pump inhibitors (PPIs) are used by millions of patients for the treatment of stomach acid\u2010reflux diseases. Although PPIs are generally considered safe, about 13% of the users develop hypomagnesemia. Despite rising attention for this issue, the underlying mechanism is still unknown. Here, we examine whether the gut microbiome is involved in the development of PPI\u2010induced hypomagnesemia in wild\u2010type C57BL\/6J mice. After 4 wk of treatment under normal or low dietary Mg\n                    <jats:sup>2+<\/jats:sup>\n                    availability, omeprazole significantly reduced serum Mg\n                    <jats:sup>2+<\/jats:sup>\n                    levels only in mice on a low\u2010Mg\n                    <jats:sup>2+<\/jats:sup>\n                    diet without affecting the mRNA expression of colonic or renal Mg\n                    <jats:sup>2+<\/jats:sup>\n                    transporters. Overall, 16S rRNA gene sequencing revealed a lower gut microbial diversity in omeprazole\u2010treated mice. Omeprazole induced a shift in microbial composition, which was associated with a 3\u2010 and 2\u2010fold increase in the abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , respectively. To examine the metabolic consequences of these microbial alterations, the colonic composition of organic acids was evaluated. Low dietary Mg\n                    <jats:sup>2+<\/jats:sup>\n                    intake, independent of omeprazole treatment, resulted in a 10\u2010fold increase in formate levels. Together, these results imply that both omeprazole treatment and low dietary Mg\n                    <jats:sup>2+<\/jats:sup>\n                    intake disturb the gut internal milieu and may pose a risk for the malabsorption of Mg\n                    <jats:sup>2+<\/jats:sup>\n                    in the colon.\u2014Gommers, L. M. M., Ederveen, T. H. A., van der Wijst, J., Overmars\u2010Bos, C., Kortman, G. A. M., Boekhorst, J., Bindels, R. J. M., de Baaij, J. H. F., Hoenderop, J. G. J. Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI\u2010induced hypomagnesemia. FASEB J. 33, 11235\u201311246 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201900839r","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T17:06:15Z","timestamp":1562951175000},"page":"11235-11246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI\u2010induced hypomagnesemia"],"prefix":"10.1096","volume":"33","author":[{"given":"Lisanne M. M.","family":"Gommers","sequence":"first","affiliation":[{"name":"Department of Physiology Radboud University Medical Center (Radboudumc) Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H. A.","family":"Ederveen","sequence":"additional","affiliation":[{"name":"Center for Molecular and Biomolecular Informatics (CMBI) Radboud Institute for Molecular Life Sciences (RIMLS) Radboud University Medical Center (Radboudumc) Nijmegen The Netherlands"},{"name":"NIZO Food Research Ede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"van der Wijst","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud University Medical Center (Radboudumc) Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caro","family":"Overmars-Bos","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud University Medical Center (Radboudumc) Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guus A. 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