{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:59:50Z","timestamp":1790697590429,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["213694"],"award-info":[{"award-number":["213694"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["223273"],"award-info":[{"award-number":["223273"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recent studies suggest that both high and low levels of vitamin B12 (vitB12) may have negative health impacts. We measured VitB12 in patients with the Neurodevelopmental disorders (ND) (n\u00a0=\u00a0222), comprised of Autism Spectrum Disorders, specific Developmental disorders, and Intellectual Disability (aged 2\u201053\u00a0years), schizophrenia (n\u00a0=\u00a0401), and healthy controls (HC) (n\u00a0=\u00a0483). Age\u2010and gender\u2010adjusted vitB12 z\u2010scores were calculated by comparisons with a reference population (n\u00a0=\u00a076\u00a0148). We found higher vitB12 in ND (median 420\u00a0pmol\/L, mean z\u2010score: 0.30) than in HC (316\u00a0pmol\/L, z\u2010score: 0.06,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.01) and schizophrenia (306\u00a0pmol\/L, z\u2010score: \u22120.02,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), which was significant after adjusting for age, gender, vitB12 supplement, folate, hemoglobin, leukocytes, liver, and kidney function (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.02). In ND, 20% (n\u00a0=\u00a044) had vitB12 above 650\u00a0pmol\/L, and 1% (n\u00a0=\u00a03) had below 150\u00a0pmol\/L (common reference limits). In 6.3% (n\u00a0=\u00a014) of ND, vitB12 was above 2SD of mean in the age\u2010and gender\u2010adjusted reference population, which was more frequent than in HC (n\u00a0=\u00a08, 1.6%), OR: 4.0,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.001. Low vitB12 was equally frequent as in HC, and vitB12 z\u2010scores were equal across the age groups. To conclude, vitB12 was higher in ND than in HC and schizophrenia, suggesting a specific feature of ND, which warrants further studies to investigate the underlying mechanisms.\n                  <\/jats:p>","DOI":"10.1096\/fj.201900855rrr","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:26Z","timestamp":1587600026000},"page":"8114-8124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia"],"prefix":"10.1096","volume":"34","author":[{"given":"Sigrun","family":"Hope","sequence":"first","affiliation":[{"name":"Department of Neuro Habilitation Oslo University Hospital Ullev\u00e5l Oslo Norway"},{"name":"NORMENT, Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine University of Oslo Oslo 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