{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:35:58Z","timestamp":1789724158412,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R56AG056696\u201001"],"award-info":[{"award-number":["1R56AG056696\u201001"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    Adiponectin (APN), an adipocyte\u2010derived adipokine, has been shown to limit lung injury originating from endothelial cell (EC) damage. Previously we reported that obese mice with low circulatory APN levels exhibited pulmonary vascular endothelial dysfunction. This study was designed to investigate the cellular and molecular mechanisms underlying the pulmonary endothelium\u2010dependent protective effects of APN. Our results demonstrated that in APN\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, there was an inherent state of endothelium mitochondrial dysfunction that could contribute to endothelial activation and increased susceptibility to LPS\u2010induced acute lung injury (ALI). We noted that APN\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice showed decreased expression of mitochondrial biogenesis regulatory protein peroxisome proliferator\u2010activated receptor \u03b3 coactivator 1\u2010\u03b1 (PGC\u20101\u03b1) and its downstream proteins nuclear respiratory factor 1, transcription factor A, mitochondrial, and Sirtuin (Sirt)3 and Sirt1 expression in whole lungs and in freshly isolated lung ECs from these mice at baseline and subjected to LPS\u2010induced ALI. We further showed that treating APN\n                    <jats:sup>_\/_<\/jats:sup>\n                    mice with PGC\u20101\u03b1 activator pyrroloquinoline quinone enhances mitochondrial biogenesis and function in lung endothelium and attenuation of ALI. These results suggest that the pulmonary endothelium\u2010protective properties of APN are mediated, at least in part, by an enhancement of mitochondrial biogenesis through a mechanism involving PGC\u20101\u03b1 activation.\u2014Shah, D., Torres, C., Bhandari, V. Adiponectin deficiency induces mitochondrial dysfunction and promotes endothelial activation and pulmonary vascular injury. FASEB J. 33, 13617\u201013631 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201901123r","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T19:16:51Z","timestamp":1570216611000},"page":"13617-13631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Adiponectin deficiency induces mitochondrial dysfunction and promotes endothelial activation and pulmonary vascular injury"],"prefix":"10.1096","volume":"33","author":[{"given":"Dilip","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Pediatrics Drexel University College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, Microbiology and Immunology Drexel University College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Drexel University College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60331"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050333"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00180-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-91137-3_19"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.05.089"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00149613"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100426"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11362"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.01.055"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-011-9330-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110367"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81113"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09459-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31820eda5c"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001577"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181cd8c08"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120722"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124329"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1475"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0329-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29623"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0194OC"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.08.027"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0270"},{"key":"e_1_2_8_26_1","article-title":"Diet\u2010induced obesity induces endoplasmic reticulum stress in the lung endothelium and predispose to LPS induced acute lung injury","volume":"193","author":"Shah D.","year":"2016","journal-title":"Am. 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