{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:39:26Z","timestamp":1762087166958,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006488","name":"Institut National de la Recherche Agronomique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Muscle atrophy is associated with many diseases including genetic disorders, sarcopenia, or cachexia syndromes. Myostatin (\n                    <jats:italic>Mstn<\/jats:italic>\n                    ), a transforming growth factor\u2010beta (TGF\u2010\u03b2) member, plays a key role in skeletal muscle homeostasis as a powerful negative regulator. Over the last decade, about 15 clinical trials aimed at inhibiting the\n                    <jats:italic>Mstn<\/jats:italic>\n                    pathway, failed to produce conclusive results. In this context, we investigated whether growth and differentiation factor\u2010associated serum protein\u20101 (GASP\u20101) or GASP\u20102, two natural inhibitors of\n                    <jats:italic>Mstn<\/jats:italic>\n                    , might represent a potential therapeutic. As we previously reported, mice overexpressing\n                    <jats:italic>Gasp\u20101<\/jats:italic>\n                    (\n                    <jats:italic>Tg(Gasp\u20101)<\/jats:italic>\n                    ) present an increase of muscle mass but develop metabolic disorders with aging. Here, we showed that overexpression of\n                    <jats:italic>Gasp\u20102<\/jats:italic>\n                    increases the muscular mass without metabolic defects. We also found that\n                    <jats:italic>Tg(Gasp\u20102)<\/jats:italic>\n                    mice displayed, like\n                    <jats:italic>Mstn<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, a switch from slow\u2010 to fast\u2010twitch myofibers whereas\n                    <jats:italic>Tg(Gasp\u20101)<\/jats:italic>\n                    mice exhibit a reverse switch. Our studies supported the fact that GASP\u20102 has less affinity than GASP\n                    <jats:italic>\u2010<\/jats:italic>\n                    1 for\n                    <jats:italic>Mstn<\/jats:italic>\n                    , leading to a constitutive\n                    <jats:italic>Mstn<\/jats:italic>\n                    upregulation only in\n                    <jats:italic>Tg(Gasp\u20101)<\/jats:italic>\n                    mice, responsible for the observed phenotypic differences. Altogether, our findings highlighted a gene expression regulatory network of TGF\u2010\u03b2 members and their inhibitors in muscle.\n                  <\/jats:p>","DOI":"10.1096\/fj.201901220r","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:17:25Z","timestamp":1579565845000},"page":"4026-4040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["GASP\u20102 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP\u20101 transgenics"],"prefix":"10.1096","volume":"34","author":[{"given":"Alexis","family":"Parent\u00e9","sequence":"first","affiliation":[{"name":"INRA, PEIRENE EA7500, USC1061 GAMAA Universit\u00e9 de Limoges Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Boukredine","sequence":"additional","affiliation":[{"name":"INRA, PEIRENE EA7500, USC1061 GAMAA Universit\u00e9 de Limoges Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Baraige","sequence":"additional","affiliation":[{"name":"INRA, PEIRENE EA7500, USC1061 GAMAA Universit\u00e9 de Limoges Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Duprat","sequence":"additional","affiliation":[{"name":"INRA, PEIRENE EA7500, USC1061 GAMAA Universit\u00e9 de Limoges Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Gondran\u2010Tellier","sequence":"additional","affiliation":[{"name":"INRA, PEIRENE EA7500, USC1061 GAMAA Universit\u00e9 de Limoges Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Magnol","sequence":"additional","affiliation":[{"name":"INRA, PEIRENE EA7500, USC1061 GAMAA Universit\u00e9 de Limoges Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Blanquet","sequence":"additional","affiliation":[{"name":"INRA, PEIRENE EA7500, USC1061 GAMAA Universit\u00e9 de Limoges Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20524-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.1215"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00019.2003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001710202"},{"issue":"10","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-213X-10-21","article-title":"Dynamics of muscle fibre growth during postnatal mouse development","volume":"22","author":"White RB","year":"2010","journal-title":"BMC Dev 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GASP\u20101 N\u2010glycosylation is not essential for its activity on C2C12 myogenic cells but alters its secretion","volume":"30","author":"Brun C","year":"2012","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"e_1_2_9_19_1","first-page":"39","article-title":"Enhancement of C2C12 myoblast proliferation and differentiation by GASP\u20102, a myostatin inhibitor","volume":"3","author":"P\u00e8ri\u00e9 L","year":"2016","journal-title":"Biochem Biophys Rep"},{"issue":"13","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1186\/1471-2164-13-541","article-title":"Ubiquitous Gasp1 overexpression in mice leads mainly to a hypermuscular phenotype","volume":"10","author":"Monestier O","year":"2012","journal-title":"BMC Genom"},{"issue":"5","key":"e_1_2_9_21_1","first-page":"1896","article-title":"Alterations in adiposity and glucose homeostasis in adult Gasp\u20101 overexpressing mice","volume":"44","author":"P\u00e9ri\u00e8 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