{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T01:05:29Z","timestamp":1777165529273,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL\u2010007852"],"award-info":[{"award-number":["HL\u2010007852"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    Despite the prevalence of CO\n                    <jats:sub>2<\/jats:sub>\n                    retention in human disease, little is known about the adaptive neurobiological effects of chronic hypercapnia. We have recently shown 30\u2010d exposure to increased inspired CO\n                    <jats:sub>2<\/jats:sub>\n                    (InCO\n                    <jats:sub>2<\/jats:sub>\n                    ) leads to a steady\u2010state ventilation that exceeds the level predicted by the sustained acidosis and the acute CO\n                    <jats:sub>2<\/jats:sub>\n                    \/H\n                    <jats:sup>+<\/jats:sup>\n                    chemoreflex, suggesting plasticity within respiratory control centers. Based on data showing brainstem changes in aminergic and inflammatory signaling during carotid body denervation\u2010induced hypercapnia, we hypothesized chronic hypercapnia\n                    <jats:italic>per se<\/jats:italic>\n                    will lead to similar changes. We found that:\n                    <jats:italic>1<\/jats:italic>\n                    ) increased InCO\n                    <jats:sub>2<\/jats:sub>\n                    increased IL\u20101\u03b2 in the medullary raphe (MR), ventral respiratory column, and cuneate nucleus after 24 h, but not after 30 d of hypercapnia;\n                    <jats:italic>2<\/jats:italic>\n                    ) the number of serotonergic and total neurons were reduced within the MR and ventrolateral medulla following 30 d of increased InCO\n                    <jats:sub>2<\/jats:sub>\n                    ;\n                    <jats:italic>3<\/jats:italic>\n                    ) markers of tryptophan metabolism were altered following 24 h, but not 30 d of InCO\n                    <jats:sub>2<\/jats:sub>\n                    ; and\n                    <jats:italic>4<\/jats:italic>\n                    ) there were few changes in brainstem amine levels following 24 h or 30 d of increased InCO\n                    <jats:sub>2<\/jats:sub>\n                    . We conclude that these changes may contribute to initiating or maintaining respiratory neuroplasticity during chronic hypercapnia but alone do not account for ventilatory acclimatization to chronic increased InCO\n                    <jats:sub>2<\/jats:sub>\n                    .\u2014Burgraff, N. J., Neumueller, S. E., Buchholz, K. J., LeClaire, J., Hodges, M. R., Pan, L., Forster, H. V. Brainstem serotonergic, catecholaminergic, and inflammatory adaptations during chronic hypercapnia in goats. FASEB J. 33, 14491\u201014505 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201901288rr","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T14:51:20Z","timestamp":1572533480000},"page":"14491-14505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Brainstem serotonergic, catecholaminergic, and inflammatory adaptations during chronic hypercapnia in goats"],"prefix":"10.1096","volume":"33","author":[{"given":"Nicholas J.","family":"Burgraff","sequence":"first","affiliation":[{"name":"Department of Physiology Wauwatosa Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne E.","family":"Neumueller","sequence":"additional","affiliation":[{"name":"Department of Physiology Wauwatosa Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirstyn J.","family":"Buchholz","sequence":"additional","affiliation":[{"name":"Department of Physiology Wauwatosa Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"LeClaire","sequence":"additional","affiliation":[{"name":"Department of Physiology Wauwatosa Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Department of Physiology Wauwatosa Wisconsin USA"},{"name":"Neuroscience Research Center Medical College of Wisconsin Wauwatosa Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Marquette University Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert V.","family":"Forster","sequence":"additional","affiliation":[{"name":"Department of Physiology Wauwatosa Wisconsin USA"},{"name":"Neuroscience Research Center Medical College of Wisconsin Wauwatosa Wisconsin USA"},{"name":"Zablocki Veterans Affairs Medical Center Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-30"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00030103"},{"key":"e_1_2_7_4_1","first-page":"199","article-title":"Hypoxemia in patients with COPD: cause, effects, and disease progression","volume":"6","author":"Kent B.D.","year":"2011","journal-title":"Int. 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