{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:26:24Z","timestamp":1790007984334,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    Gut\u2010homing \u03b3\u03b4 T cells are induced by chemokines and cell adhesion molecules and play a critical role in homeostasis and mucosal immunity; however, little is known regarding their upstream regulators. We investigated the role of Axl as a specific regulator of chemokines and cell adhesion molecule in the distribution of intestinal\n                    <jats:italic>\u03b3\u03b4<\/jats:italic>\n                    T cells. The population of \u03b3\u03b4 T\u2010cell receptor\u2010positive cells including V\u03b31 and V\u03b37 subsets was remarkably increased in the intraepithelial lymphocytes of Axl mice compared with those of wild\u2010type (WT) mice. An increased number of migrated \u03b3\u03b4 T cells were observed in the coculture with intraepithelial cells from Axl\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. The mRNA expression level of chemokine (C\u2010C motif) ligand (CCL) 25 was specifically higher in the small intestine of Axl\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice than in WT mice. In adoptive transfer, the migration of both thymic and extrathymic \u03b3\u03b4 T cells was increased in Axl\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. The activation of Axl signaling down\u2010regulated CCL25 expression\n                    <jats:italic>via<\/jats:italic>\n                    ERK signaling pathway and reduced the population of \u03b3\u03b4 T cells. Systemic dissemination was suppressed in Axl\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice infected with\n                    <jats:italic>Salmonella typhimurium.<\/jats:italic>\n                    Thus, our findings suggest that Axl plays a critical role in regulating the migration of \u03b3\u03b4 T cells for the maintenance of homeostasis and bacterial resistance.\u2014Kim, S.\u2010M., Park, M., Yee, S.\u2010M., Ji, K.\u2010Y., Lee, E.\u2010H., Nguyen, T.\u2010V., Nguyen, T. H.\u2010L., Jang, J., Kim, E.\u2010M., Choi, H.\u2010R., Yun, C.\u2010H., Kang, H.\u2010S. Axl is a key regulator of intestinal \u03b3\u03b4 T\u2010cell homeostasis. FASEB J. 33, 13386\u201313397 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201901356r","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T15:32:48Z","timestamp":1569339168000},"page":"13386-13397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Axl is a key regulator of intestinal\n                    <i>\u03b3\u03b4<\/i>\n                    T\u2010cell homeostasis"],"prefix":"10.1096","volume":"33","author":[{"given":"Su\u2010Man","family":"Kim","sequence":"first","affiliation":[{"name":"School of Biological Sciences and Technology Chonnam National University Gwangju South 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