{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T11:22:28Z","timestamp":1782645748447,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    ATPase inhibitory factor 1 (IF1) is an ATP synthase\u2010interacting protein that suppresses the hydrolysis activity of ATP synthase. In this study, we observed that the expression of IF1 was up\u2010regulated in response to electrical pulse stimulation of skeletal muscle cells and in exercized mice and healthy men. IF1 stimulates glucose uptake\n                    <jats:italic>via<\/jats:italic>\n                    AMPK in skeletal muscle cells and primary cultured myoblasts. Reactive oxygen species and Rac family small GTPase 1 (Rac1) function in the upstream and downstream of AMPK, respectively, in IF1\u2010mediated glucose uptake. In diabetic animal models, the administration of recombinant IF1 improved glucose tolerance and down\u2010regulated blood glucose level. In addition, IF1 inhibits ATP hydrolysis by \u03b2\u2010F1\u2010ATPase in plasma membrane, thereby increasing extracellular ATP and activating the protein kinase B (Akt) pathway, ultimately leading to glucose uptake. Thus, we suggest that IF1 is a novel myokine and propose a mechanism by which AMPK and Akt contribute independently to IF1\u2010mediated improvement of glucose tolerance impairment. These results demonstrate the importance of IF1 as a potential antidiabetic agent.\u2014Lee, H. J., Moon, J., Chung, I., Chung, J. H., Park, C., Lee, J. O., Han, J. A., Kang, M. J., Yoo, E. H., Kwak, S.\u2010Y., Jo, G., Park, W., Park, J., Kim, K. M., Lim, S., Ngoei, K. R. W., Ling, N. X. Y., Oakhill, J. S., Galic, S., Murray\u2010Segal, L., Kemp, B. E., Mantzoros, C. S., Krauss, R. M., Shin, M.\u2010J., Kim, H. S. ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways. FASEB J. 33, 14825\u201014840 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201901440rr","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T15:38:04Z","timestamp":1572536284000},"page":"14825-14840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways"],"prefix":"10.1096","volume":"33","author":[{"given":"Hye Jeong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Korea University Seoul South Korea"},{"name":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"InHyeok","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Biotechnology CHA University Pocheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biotechnology CHA University Pocheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ah","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ju","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hye","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Young","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garam","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonil","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physical Education Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physical Education Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R. W.","family":"Ngoei","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Metabolism University of Melbourne Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi X. Y.","family":"Ling","sequence":"additional","affiliation":[{"name":"Metabolic Signaling Laboratory, St Vincenf's Institute of Medical Research, University of Melbourne Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Oakhill","sequence":"additional","affiliation":[{"name":"Metabolic Signaling Laboratory, St Vincenf's Institute of Medical Research, University of Melbourne Fitzroy Victoria Australia"},{"name":"Mary MacKillop Institute for Health Research, Australian Catholic University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Galic","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Metabolism University of Melbourne Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Murray\u2010Segal","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Metabolism University of Melbourne Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Metabolism University of Melbourne Fitzroy Victoria Australia"},{"name":"Mary MacKillop Institute for Health Research, Australian Catholic University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Beth\u2010Israel Deaconess Medical Center\u2010Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Jeong","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/414782a"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.05.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-017-1037-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0711-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.01.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00097"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3224-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1404"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1062"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0490"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2005.12.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.065"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1106"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb966"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.10.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/35089509"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.03.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75338-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.06.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.1.C209"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00053"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.146480"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.01.008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.10.016"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405947200"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-018-0641-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.06.041"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01250"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10944"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.110601"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100569"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0011"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.03.006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3215.269"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.21387"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6357"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1913"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4379-z"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12991"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11251-8"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.36.115"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1139\/H07-026"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105062108"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8244-6"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.01979.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00239.2009"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01269.2005"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000017"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1066"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.3"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00056-5"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10185SC"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.057315"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2002"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201901440RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201901440RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201901440RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:49:42Z","timestamp":1761688182000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201901440RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1096\/fj.201901440RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.201901440rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,31]]},"assertion":[{"value":"2019-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}