{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T15:24:34Z","timestamp":1776612274770,"version":"3.51.2"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010218","name":"Department of Science and Technology, Philippines","doi-asserted-by":"publisher","award":["PDF\/2015\/000790"],"award-info":[{"award-number":["PDF\/2015\/000790"]}],"id":[{"id":"10.13039\/501100010218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An inverse correlation between helminth infection and the autoimmune disease appears to be contributed by the anti\u2010inflammatory factors produced by these organisms. Suppressing osteoclast function without affecting the systemic immunological response is an emerging therapeutic strategy for rheumatoid arthritis (RA). We observed that a synthetic peptide corresponding to 34 amino acids of C\u2010terminal sequence of\n                    <jats:italic>Fasciola<\/jats:italic>\n                    helminth defense molecule\u20101 (C\u2010FhHDM\u20101) inhibited RANKL\u2010induced osteoclast formation and lysosomal acidification with an attendant upregulation of sequestome1\/p62, a negative regulator of NF\u2010\u03baB expression. C\u2010FhHDM\u20101 also suppressed RANKL production from osteoblasts. Macrophages are the major inflammatory cells in the joints of RA and C\u2010FhHDM\u20101 suppressed ICAM\u20101 (an inflammatory surrogate) expression in these cells. In a murine model of collagen II\u2010induced arthritis (CIA), C\u2010FhHDM\u20101 improved clinical score, protected against cartilage destruction, and maintained bone mass and bone architecture of joints compared with\u00a0the CIA group. C\u2010FhHDM\u20101 suppressed the CIA\u2010induced expression of TNF, IL\u201017, and IFN\u2010\u03b3 in joints but not their serum levels. The peptide also had no effect on the CIA\u2010induced suppression of T regulatory response. We conclude that C\u2010FhHDM\u20101 has a joint\u2010specific protective effect in experimental arthritis without mitigating systemic inflammation, and thus could become an adjuvant anti\u2010arthritis therapy to prevent RA\u2010induced osteopenia.\n                  <\/jats:p>","DOI":"10.1096\/fj.201901480rr","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T01:10:30Z","timestamp":1574989830000},"page":"1091-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>Fasciola<\/i>\n                    helminth defense molecule\u20101 protects against experimental arthritis by inhibiting osteoclast formation and function without modulating the systemic immune response"],"prefix":"10.1096","volume":"34","author":[{"given":"Yasir Akhtar","family":"Khan","sequence":"first","affiliation":[{"name":"Division of Endocrinology CSIR\u2010Central Drug Research Institute Lucknow 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