{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:52:52Z","timestamp":1791395572212,"version":"4.3.3"},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR063649"],"award-info":[{"award-number":["R01\u2010AR063649"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32\u2010AR067086"],"award-info":[{"award-number":["F32\u2010AR067086"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Tenocytes serve to synthesize and maintain collagen fibrils and other extracellular matrix proteins in tendon. Despite the high prevalence of tendon injury, the underlying biologic mechanisms of postnatal tendon growth and repair are not well understood. IGF1 plays an important role in the growth and remodeling of numerous tissues but less is known about IGF1 in tendon. We hypothesized that IGF1 signaling is required for proper tendon growth in response to mechanical loading through regulation of collagen synthesis and cell proliferation. To test this hypothesis, we conditionally deleted the IGF1 receptor (\n                    <jats:italic>IGF1R<\/jats:italic>\n                    ) in scleraxis (\n                    <jats:italic>Scx<\/jats:italic>\n                    )\u2010expressing tenocytes using a tamoxifen\u2010inducible\n                    <jats:italic>Cre<\/jats:italic>\n                    \u2010recombinase system and caused tendon growth in adult mice\n                    <jats:italic>via<\/jats:italic>\n                    mechanical overload of the plantaris tendon. Compared with control\n                    <jats:italic>Scx<\/jats:italic>\n                    \u2010expressing\n                    <jats:italic>IGF1R<\/jats:italic>\n                    \u2010positive (\n                    <jats:italic>Scx:IGF1R<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    ) mice, in which IGF1R is present in tenocytes, mice that lacked\n                    <jats:italic>IGF1R<\/jats:italic>\n                    in their tenocytes [\n                    <jats:italic>Scx<\/jats:italic>\n                    \u2010expressing\n                    <jats:italic>IGF1R<\/jats:italic>\n                    \u2010negative (\n                    <jats:italic>Scx:IGF1R<\/jats:italic>\n                    <jats:sup>\u0394<\/jats:sup>\n                    ) mice] demonstrated reduced cell proliferation and smaller tendons in response to mechanical loading. Additionally, we identified that both the PI3K\/protein kinase B and ERK pathways are activated downstream of IGF1 and interact in a coordinated manner to regulate cell proliferation and protein synthesis. These studies indicate that IGF1 signaling is required for proper postnatal tendon growth and support the potential use of IGF1 in the treatment of tendon disorders.\u2014Disser, N. P., Sugg, K. B., Talarek, J. R., Sarver, D. C., Rourke, B. J., Mendias, C. L. Insulin\u2010like growth factor 1 signaling in tenocytes is required for adult tendon growth. FASEB J. 33, 12680\u201312695 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201901503r","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T14:00:16Z","timestamp":1568901616000},"page":"12680-12695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Insulin\u2010like growth factor 1 signaling in tenocytes is required for adult tendon growth"],"prefix":"10.1096","volume":"33","author":[{"given":"Nathaniel P.","family":"Disser","sequence":"first","affiliation":[{"name":"Hospital for Special Surgery New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer B.","family":"Sugg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"Department of Molecular and Integrative Physiology"},{"name":"Section of Plastic and Reconstructive Surgery, Department of Surgery University of Michigan Medical School Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Talarek","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York USA"},{"name":"Department of Orthopaedic Surgery"},{"name":"Department of Molecular and Integrative Physiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan C.","family":"Sarver","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brennan J.","family":"Rourke","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York USA"},{"name":"Department of Orthopaedic Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Mendias","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York USA"},{"name":"Department of Orthopaedic Surgery"},{"name":"Department of Physiology and Biophysics Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000041"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.05.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90361.2008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00328.2016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-018-3904-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00720.2014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.213"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tsm2.6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2012.01459.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.92.2005.2.1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800459R"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.234"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01084.2013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00009-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2014.09.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010037"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45238"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00258.2017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516637176"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-168799"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3182798a95"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120044"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009731"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802457RR"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00636.2005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00674.2013"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.068858"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12571"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81589"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.001933"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.153106"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00301.2012"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100140407"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20875"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059002579.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.02.020"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-6-9"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.04.151"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2011.01431.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0818"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3902"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00157.2014"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1177"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.693598"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22426"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.12.011"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.136242"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2016.05.001"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.1.330"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.093047.109"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25951"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314124110"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9751-7"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.50.31400"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000126501.34994.96"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2644-8"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0073"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0336"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-386"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2009.00949.x"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509350915"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802366RR"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2018.11.004"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201901503R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201901503R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201901503R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:16:49Z","timestamp":1761682609000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201901503R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,16]]},"references-count":66,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1096\/fj.201901503R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201901503r","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/670026","asserted-by":"object"}]},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,16]]},"assertion":[{"value":"2019-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}