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The pigmented\n                    <jats:italic>\n                      Abca4\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mouse strain only reflects the early stage of STGD1 since it is devoid of retinal degeneration. This blue light\u2010illuminated pigmented\n                    <jats:italic>\n                      Abca4\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mouse model presented retinal pigment epithelium (RPE) and photoreceptor degeneration which was similar to the advanced STGD1 phenotype. In contrast, wild\u2010type mice showed no RPE degeneration after blue light illumination. In\n                    <jats:italic>\n                      Abca4\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice, the acute blue light diminished the mean autofluorescence (AF) intensity in both fundus short\u2010wavelength autofluorescence (SW\u2010AF) and near\u2010infrared autofluorescence (NIR\u2010AF) modalities correlating with reduced levels of bisretinoid\u2010fluorophores. Blue light\u2010induced RPE cellular damage preceded the photoreceptors loss. In late\u2010stage STGD1\u2010like patient and blue light\u2010illuminated\n                    <jats:italic>\n                      Abca4\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice, lipofuscin and melanolipofuscin granules were found to contribute to NIR\u2010AF, indicated by the colocalization of lipofuscin\u2010AF and NIR\u2010AF under the fluorescence microscope. In this mouse model, the correlation between in vivo and ex vivo assessments revealed histological characteristics of fundus AF abnormalities. The flecks which are hyper AF in both SW\u2010AF and NIR\u2010AF corresponded to the subretinal macrophages fully packed with pigment granules (lipofuscin, melanin, and melanolipofuscin). This mouse model, which has the phenotype of advanced STGD1, is important to understand the histopathology of Stargardt disease.\n                  <\/jats:p>","DOI":"10.1096\/fj.201901784rr","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T23:58:14Z","timestamp":1580169494000},"page":"3693-3714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Fundus autofluorescence, spectral\u2010domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model"],"prefix":"10.1096","volume":"34","author":[{"given":"Yuan","family":"Fang","sequence":"first","affiliation":[{"name":"Division of Experimental Vitreoretinal Surgery Center for Ophthalmology Institute of Ophthalmic Research University of Tuebingen Tuebingen 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