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This study aimed to determine if the ablation of AMPK \u03b21\u2010containing complexes potentiates acute OLZ\u2010induced metabolic dysfunction and if the activation of AMPK \u03b21 suppresses these effects. Female AMPK \u03b21\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    or wild\u2010type (WT) control mice were treated with OLZ, and changes in bloodglucose, serum and liver metabolites, whole\u2010body fuel oxidation, and pyruvate\u2010induced increases in blood glucose were measured. Additionally, WT mice were cotreated with OLZ and A769662, a specific AMPK \u03b21 activator, and we determined if cotreatment protected against acute, OLZ\u2010induced metabolic dysfunction. OLZ\u2010induced increases in blood glucose were exacerbated in AMPK \u03b21\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice compared with WT mice, and this was paralleled by greater OLZ\u2010induced increases in markers of liver glucose production, such as pyruvate tolerance, serum glucagon, and glucagon responsiveness. Cotreatment with A769662 attenuated OLZ\u2010induced increases in blood glucose, serum nonesterified fatty acid, and glycerol. Furthermore, this effect was absent in AMPK \u03b21\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice, consistent with A769662's specificity for the AMPK \u03b21 subunit. Reductions in AMPK activity potentiate the effects of acute OLZ treatment on blood glucose, whereas specifically targeting AMPK \u03b21\u2010containing complexes is sufficient to protect against OLZ\u2010induced hyperglycemia.\u2014Shamshoum, H., Medak, K. D., Townsend, L. K., Ashworth, K. E., Bush, N. D., Hahn, M. K., Kemp, B. E., Wright, D. C. AMPK \u03b21 activation suppresses antipsychotic\u2010induced hyperglycemia in mice. FASEB J. 33, 14010\u201014021 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201901820r","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T20:51:46Z","timestamp":1570135906000},"page":"14010-14021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["AMPK \u03b21 activation suppresses antipsychotic\u2010induced hyperglycemia in mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Hesham","family":"Shamshoum","sequence":"first","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle D.","family":"Medak","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan K.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen E.","family":"Ashworth","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha D.","family":"Bush","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret K.","family":"Halm","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Medicine St Vincent's Institute, University of Melbourne Melbourne Victoria Australia"},{"name":"Mary MacKillop Institute for Health Research, Australian Catholic University Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1360"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1515725"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20140009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04912gre"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/656370"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.07.022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.05.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181bfe13e"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19260-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31829e8333"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.12.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12148"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0074"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.05.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.110140"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093310"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)78143-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41951-X"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2011.12.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306205200"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1402"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10856"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.01.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.05.005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.056762"},{"issue":"2","key":"e_1_2_9_27_1","first-page":"3","article-title":"Atypical antipsychotics. sleep, sedation, and efficacy","volume":"6","author":"Miller D. 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