{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:06:26Z","timestamp":1790820386346,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-TP-105B10"],"award-info":[{"award-number":["KMU-TP-105B10"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-DK105009"],"award-info":[{"award-number":["KMU-DK105009"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-TC108A02"],"award-info":[{"award-number":["KMU-TC108A02"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-TC108A02-1"],"award-info":[{"award-number":["KMU-TC108A02-1"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chondrocytes in growth plates are responsible for longitudinal growth in long bones during endochondral ossification. Discoidin domain receptor 1 (\n                    <jats:italic>Ddr1<\/jats:italic>\n                    ) is expressed in chondrocytes, but the molecular mechanisms by which DDR1 regulates chondrocyte behaviors during the endochondral ossification process remain undefined. To elucidate\n                    <jats:italic>Ddr1<\/jats:italic>\n                    \u2010mediate chondrocyte functions, we generated chondrocyte\u2010specific\n                    <jats:italic>Ddr1<\/jats:italic>\n                    knockout (CKO\u0394\n                    <jats:italic>Ddr1<\/jats:italic>\n                    ) mice in this study. The CKO\u0394\n                    <jats:italic>Ddr1<\/jats:italic>\n                    mice showed delayed development of the secondary ossification center and increased growth plate length in the hind limbs. In the tibial growth plate in CKO\u0394\n                    <jats:italic>Ddr1<\/jats:italic>\n                    mice, chondrocyte proliferation was reduced in the proliferation zone, and remarkable downregulation of Ihh, MMP13, and Col\u2010X expression in chondrocytes resulted in decreased terminal differentiation in the hypertrophic zone. Furthermore, apoptotic chondrocytes were reduced in the growth plates of CKO\u0394\n                    <jats:italic>Ddr1<\/jats:italic>\n                    mice. We concluded that chondrocytes with\n                    <jats:italic>Ddr1<\/jats:italic>\n                    knockout exhibit decreased proliferation, terminal differentiation, and apoptosis in growth plates, which delays endochondral ossification and results in short stature. We also demonstrated that\n                    <jats:italic>Ddr1<\/jats:italic>\n                    regulates the Ihh\/Gli1\/Gli2\/Col\u2010X pathway to regulate chondrocyte terminal differentiation. These results indicate that\n                    <jats:italic>Ddr1<\/jats:italic>\n                    is required for chondrocytes to regulate endochondral ossification in skeletal development.\n                  <\/jats:p>","DOI":"10.1096\/fj.201901852rr","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T01:25:49Z","timestamp":1583285149000},"page":"5767-5781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes"],"prefix":"10.1096","volume":"34","author":[{"given":"Liang\u2010Yin","family":"Chou","sequence":"first","affiliation":[{"name":"Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Hwan","family":"Chen","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Institute of Medical Science and Technology National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsiung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Lipid Science and Aging Research Center Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Chun","family":"Chuang","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Chiao","family":"Chou","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Yen","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010Chi","family":"Fu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je\u2010Ken","family":"Chang","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Division of Adult Reconstruction Surgery Department of Orthopedics Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Physiology College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau\u2010Zen","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Centre Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Physiology College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.02.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1696"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0096"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605170103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21072"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01461"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3117"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.16.2072"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2014.12.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.5.457"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2000.0932"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9346-z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.12.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve094"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800180-6.00002-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.09.089"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.05.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1436-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20892"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0701806"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.023820"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.129"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.021436"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.19.8581-8591.2005"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v028a19"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v024a09"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1174704"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23289"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.570507"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<145::AID-GENE14>3.0.CO;2-C"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2287"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.3.543"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030874"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00415-09"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1096%2Ffj.201901852RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201901852RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201901852RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201901852RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:01:59Z","timestamp":1761681719000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201901852RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1096\/fj.201901852RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.201901852rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,3]]},"assertion":[{"value":"2019-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}