{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:07:13Z","timestamp":1790809633064,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    Inflammatory stimuli, such as bacterial LPS, alter the expression of many cytochromes P450. CYP2C and CYP2J subfamily members actively metabolize fatty acids to bioactive eicosanoids, which exhibit potent anti\u2010inflammatory effects. Herein, we examined mRNA levels of the 15 mouse\n                    <jats:italic>Cyp2c<\/jats:italic>\n                    and 7 mouse\n                    <jats:italic>Cyp2j<\/jats:italic>\n                    isoforms in liver, kidney, duodenum, and brain over a 96\u2010h time course of LPS\u2010induced inflammation and resolution. Plasma and liver eicosanoid levels were also measured by liquid chromatography with tandem mass spectrometry. Expression changes in\n                    <jats:italic>Cyp2c<\/jats:italic>\n                    and\n                    <jats:italic>Cyp2j<\/jats:italic>\n                    isoforms were both isoform and tissue specific. Total liver\n                    <jats:italic>Cyp2c<\/jats:italic>\n                    and\n                    <jats:italic>Cyp2j<\/jats:italic>\n                    mRNA content was reduced by 80% 24 h after LPS but recovered to baseline levels by 96 h. Total\n                    <jats:italic>Cyp2c<\/jats:italic>\n                    and\n                    <jats:italic>Cyp2j<\/jats:italic>\n                    mRNA in kidney (\u201019%) and duodenum (\u201064%) were reduced 24 h after LPS but recovered above baseline by 72 h. Total\n                    <jats:italic>Cyp2c<\/jats:italic>\n                    and\n                    <jats:italic>Cyp2j<\/jats:italic>\n                    mRNA content in brain was elevated at all time points after LPS dosing. Plasma eicosanoids transiently increased 3\u20106 h after administration of LPS. In liver, esterified oxylipin levels decreased during acute inflammation and before recovering. The biphasic suppression and recovery of mouse\n                    <jats:italic>Cyp2c<\/jats:italic>\n                    and\n                    <jats:italic>Cyp2j<\/jats:italic>\n                    isoforms and associated changes in eicosanoid levels during LPS\u2010induced inflammation and resolution may have important physiologic consequences.\u2014Graves, J. P., Bradbury, J. A., Gruzdev, A., Li, H., Duval, C., Lih, F. B., Edin, M. L., Zeldin, D. C. Expression of\n                    <jats:italic>Cyp2c\/Cyp2j<\/jats:italic>\n                    subfamily members and oxylipin levels during LPS\u2010induced inflammation and resolution in mice. FASEB J. 33, 14784\u201014797 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201901872r","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T22:34:21Z","timestamp":1572993261000},"page":"14784-14797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Expression of\n                    <i>Cyp2c\/Cyp2j<\/i>\n                    subfamily members and oxylipin levels during LPS\u2010induced inflammation and resolution in mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Joan P.","family":"Graves","sequence":"first","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alyce","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artiom","family":"Gruzdev","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Duval","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred B.","family":"Lih","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Edin","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C.","family":"Zeldin","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200206000-00007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11203-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199602000-00002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32049-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2016.04.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000298"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.04.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.97"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.057174"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.035287"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5431.1276"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-171488"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2013.02.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.117.075697"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.064139"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2217-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2875"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP316"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177729885"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0250169"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59524-0_3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0370-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602539709002246"},{"key":"e_1_2_8_27_1","first-page":"207","article-title":"Regulation of cytochrome p450 by inflammatory mediators: why and how?","volume":"29","author":"Morgan E. 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