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Here, using self\u2010limited\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    peritonitis in mice, we identified endogenous maresin (MaR) CTR (MCTR), protectin (PD) CTR (PCTR), and resolvin CTR in infectious peritoneal exudates and distal spleens, as well as investigated enzymes involved in their biosynthesis. PCTRs were identified to be temporally regulated in peritoneal exudates and spleens. PCTR1 and MCTR1 were each produced by human recombinant leukotriene (LT) C\n                    <jats:sub>4<\/jats:sub>\n                    synthase (LTC\n                    <jats:sub>4<\/jats:sub>\n                    S) and glutathione S\u2010transferases (GSTs) [microsomal GST (mGST)2, mGST3, and GST\u2010\u03bc (GSTM)4] from their epoxide precursors [16\n                    <jats:italic>S<\/jats:italic>\n                    ,17\n                    <jats:italic>S<\/jats:italic>\n                    \u2010epoxy\u2010PD (ePD) and 13\n                    <jats:italic>S<\/jats:italic>\n                    ,14\n                    <jats:italic>S<\/jats:italic>\n                    \u2010epoxy\u2010MaR (eMaR)], with preference for GSTM4. Both eMaR and ePD inhibited LTB4 production by LTA\n                    <jats:sub>4<\/jats:sub>\n                    hydrolase. LTC\n                    <jats:sub>4<\/jats:sub>\n                    S, mGST2, mGST3, and GSTM4 were each expressed in human M1\u2010 and M2\u2010like macrophages where LTC\n                    <jats:sub>4<\/jats:sub>\n                    S inhibition increased CTRs. Finally, PCTR1 showed potent analgesic action. These results demonstrate CTR biosynthesis in mouse peritonitis, human spleens, and human macrophages, as well as identification of key enzymes in these pathways. Moreover, targeting LTC\n                    <jats:sub>4<\/jats:sub>\n                    S increases CTR metabolomes, giving a new strategy to stimulate resolution and tissue regeneration.\u2014Jouvene, C. C., Shay, A. E., Soens, M. A., Norris, P. C., Haeggstr\u00f6m, J. Z., Serhan, C. N. Biosynthetic metabolomes of cysteinyl\u2010containing immunoresolvents. FASEB J. 33, 13794\u201013807 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201902003r","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T18:03:05Z","timestamp":1570471385000},"page":"13794-13807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Biosynthetic metabolomes of cysteinyl\u2010containing immunoresolvents"],"prefix":"10.1096","volume":"33","author":[{"given":"Charlotte C.","family":"Jouvene","sequence":"first","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative, and Pain Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley E.","family":"Shay","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative, and Pain Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke A.","family":"Soens","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative, and Pain Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Norris","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative, and Pain Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts 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