{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:26:25Z","timestamp":1785536785449,"version":"3.56.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31500760, 51777211 and 31670953"],"award-info":[{"award-number":["No. 31500760, 51777211 and 31670953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The skeleton of type 1 diabetes mellitus (T1DM) has deteriorated mechanical integrity and increased fragility, whereas the mechanisms are not fully understood. Load\u2010induced microdamage naturally occurs in bone matrix and can be removed by initiating endogenous targeted bone remodeling. However, the microdamage accumulation in diabetic skeleton and the corresponding bone remodeling mechanisms remain poorly understood. Herein, streptozotocin\u2010induced T1DM rats and age\u2010matched non\u2010diabetic rats were subjected to daily uniaxial ulnar loading for 1, 4, 7, and 10 days, respectively. The SPECT\/CT and basic fuchsin staining revealed significant higher\u2010density spatial accumulation of linear and diffuse microdamage in diabetic ulnae than non\u2010diabetic ulnae. Linear microcracks increased within 10\u2010day loading in diabetic bone, whereas peaked at Day 7 in non\u2010diabetic bone. Moreover, diabetic fatigued ulnae had more severe disruptions of osteocyte canaliculi around linear microcracks. Immunostaining results revealed that diabetes impaired targeted remodeling in fatigued bone at every key stage, including increased apoptosis of bystander osteocytes, decreased RANKL secretion, reduced osteoclast recruitment and bone resorption, and impaired osteoblast\u2010mediated bone formation. This study characterizes microdamage accumulation and abnormal remodeling mechanisms in the diabetic skeleton, which advances our etiologic understanding of diabetic bone deterioration and increased fragility from the aspect of microdamage accumulation and bone remodeling.<\/jats:p>","DOI":"10.1096\/fj.201902011rr","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T23:55:15Z","timestamp":1576713315000},"page":"2579-2594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Spatiotemporal characterization of microdamage accumulation and its targeted remodeling mechanisms in diabetic fatigued bone"],"prefix":"10.1096","volume":"34","author":[{"given":"Xiyu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Basic Medicine Shaanxi University of Chinese Medicine Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zedong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangning","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. 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